DegronMD

Uniprot ID: O15516

Source protein: Circadian locomoter output cycles protein kaput

Source gene: CLOCK

Class: DEG_SCF_FBW7_1

Location: 428:433

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 88.6333

COIL: 0.9517

CONS_SCORE: 0.4715

DSS_SCORE: 0.6944

HELIX: 0.0315

FCONS_SCORE: 1.0709

RIG_SCORE: 0.5403

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S431A	TCGA-18-3410	LUSC	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.7588
p.S431A	DO26456	LUSC	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.7588
p.H442Y	TCGA-VQ-A8PP	STAD	TCGA	PTPSAS	DEG_SCF_FBW7_1	0.0833
p.H442Y	DO51774	STAD	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.0833
p.S427R	DO229038	LICA	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.75
p.P428R	DO46390	OV	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.7512
p.R435L	DO229250	THCA	ICGC	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	SIDM00313	Hodgkin's Lymphoma	GDSC	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	ACH-000702	Lymphoma	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	ACH-000865	Esophageal Cancer	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	ACH-001533	Lymphoma	CCLE	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	L-1236	haematopoietic_and_lymphoid_tissue	COSMIC	PTPSAS	DEG_SCF_FBW7_1	0.2778
p.R435Q	KYSE-450	oesophagus	COSMIC	PTPSAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15516	Circadian locomoter output cycles protein kaput	DEG_SCF_FBW7_1	428:433	PTPSAS	FBXW7	0.9968	More...
P41587	Vasoactive intestinal polypeptide receptor 2	DEG_SCF_FBW7_1	395:400	PTPSAS	FBXW7	0.7761	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons