DegronMD - Q9H7E9(C8orf33)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R24S	TCGA-28-5211	GBM	TCGA	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.3056
p.R24S	DO11016	GBM	ICGC	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.3056
p.R24S	ACH-001333	Cervical Cancer	CCLE	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.3056
p.E173K	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1667
p.E173K	TCGA-DD-AACF	LIHC	TCGA	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1667
p.E173K	DO52201	LIHC	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1667
p.E173K	DO41235	UCEC	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1667
p.R167M	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	165:167	Mutation altering degron motif	0.8632
p.R167M	DO42280	UCEC	ICGC	DYR	CBL_MET	165:167	Mutation altering degron motif	0.8632
p.A14V	TCGA-D5-6529	COAD	TCGA	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.25
p.A14V	DO10758	COAD	ICGC	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.25
p.H160R	TCGA-D7-A6EY	STAD	TCGA	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1944
p.H160R	DO50118	STAD	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1944
p.L7P	TCGA-W5-AA39	CHOL	TCGA	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.0556
p.Q169H	DO222830	BTCA	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2778
p.Q169H	SIDM01752	Pancreatic Carcinoma	GDSC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2778
p.Q169H	ACH-000685	Pancreatic Cancer	CCLE	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2778
p.G18V	DO223082	ESCA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation altering degron motif	0.6421
p.A177T	DO228533	GACA	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.0556
p.R175H	DO233245	GACA	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.1111
p.E171G	DO220877	MELA	ICGC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2222
p.P20L	DO222542	MELA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation altering degron motif	0.7582
p.P15S	DO229216	THCA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	17:23	Mutation rewiring degron network	0.2778
p.S161F	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2222
p.S161F	ACH-000061	Lymphoma	CCLE	DYR	CBL_MET	165:167	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C8orf33

UniProt ID: Q9H7E9

Entrez ID: 65265

Protein name: UPF0488 protein C8orf33

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C8orf33 in