DegronMD

Uniprot ID: Q9H7E9

Source protein: UPF0488 protein C8orf33

Source gene: C8orf33

Class: DEG_SCF_FBW7_1

Location: 17:23

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 77.8571

COIL: 0.9213

CONS_SCORE: 0.2367

DSS_SCORE: 0.4635

HELIX: 0.0329

FCONS_SCORE: 1.0617

RIG_SCORE: 0.6272

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R24S	TCGA-28-5211	GBM	TCGA	PGTPCAS	DEG_SCF_FBW7_1	0.3056
p.R24S	DO11016	GBM	ICGC	PGTPCAS	DEG_SCF_FBW7_1	0.3056
p.R24S	ACH-001333	Cervical Cancer	CCLE	PGTPCAS	DEG_SCF_FBW7_1	0.3056
p.A14V	TCGA-D5-6529	COAD	TCGA	PGTPCAS	DEG_SCF_FBW7_1	0.25
p.A14V	DO10758	COAD	ICGC	PGTPCAS	DEG_SCF_FBW7_1	0.25
p.L7P	TCGA-W5-AA39	CHOL	TCGA	PGTPCAS	DEG_SCF_FBW7_1	0.0556
p.G18V	DO223082	ESCA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	0.6421
p.P20L	DO222542	MELA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	0.7582
p.P15S	DO229216	THCA	ICGC	PGTPCAS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H7E9	UPF0488 protein C8orf33	DEG_SCF_FBW7_1	17:23	PGTPCAS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons