DegronMD - Q9Y5G3(PCDHGB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A272T	TCGA-50-5944	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.A272T	DO24379	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.S286R	TCGA-55-8089	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7427
p.S286R	DO23690	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7427
p.T294N	TCGA-A5-A0G1	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.T294N	DO42472	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1111
p.D296N	TCGA-AA-A010	COAD	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.D296N	TCGA-EO-A3B0	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.D296N	DO222815	BTCA	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.D296N	DO219773	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.T285I	TCGA-AX-A2HD	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7078
p.T285I	DO42608	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7078
p.T275A	TCGA-BR-6452	STAD	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.T275A	DO38404	STAD	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.T275I	TCGA-EB-A44N	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.T275I	DO47638	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.1389
p.L290F	DO8264	COAD	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222
p.S284C	DO222739	ESCA	ICGC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.7541
p.P893T	DO233115	GACA	ICGC	DYR	CBL_MET	885:887	Mutation rewiring degron network	0.1667
p.V883M	DO25554	LUAD	ICGC	DYR	CBL_MET	885:887	Mutation rewiring degron network	0.2778
p.V883M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	885:887	Mutation rewiring degron network	0.2778
p.V890G	DO28089	OV	ICGC	DYR	CBL_MET	885:887	Mutation rewiring degron network	0.25
p.T879A	DO48918	PBCA	ICGC	DYR	CBL_MET	885:887	Mutation rewiring degron network	0.1667
p.R887H	DO41871	UCEC	ICGC	DYR	CBL_MET	885:887	Mutation altering degron motif	0.8244
p.R887C	DO42568	UCEC	ICGC	DYR	CBL_MET	885:887	Mutation altering degron motif	0.8301
p.A272V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.A272V	ACH-000636	Leukemia	CCLE	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.A272V	RPMI-8402	haematopoietic and lymphoid tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.0556
p.I283V	SIDM00570	Gastric Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00961	Ewing's Sarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00577	Neuroblastoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00231	Kidney Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00596	Endometrial Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00026	Other Solid Cancers	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM00168	Head and Neck Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.I283V	SIDM01619	Endometrial Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation altering degron motif	0.5965
p.F278S	CTB-1	haematopoietic and lymphoid tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	282:286	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGB1

UniProt ID: Q9Y5G3

Entrez ID: 56104

Protein name: Protocadherin gamma-B1 (PCDH-gamma-B1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGB1 in