DegronMD

Uniprot ID: Q9Y5G3

Source protein: Protocadherin gamma-B1

Source gene: PCDHGB1

Class: DEG_SPOP_SBC_1

Location: 282:286

E3 ligase: SPOP

DEGRON score: 0.9253

ASA_SCORE: 79.1

COIL: 0.7324

CONS_SCORE: 0.3777

DSS_SCORE: 0.1881

HELIX: 0.108

FCONS_SCORE: 0.6504

RIG_SCORE: 0.7896

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A272T	TCGA-50-5944	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.A272T	DO24379	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.0556
p.S286R	TCGA-55-8089	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	0.7427
p.S286R	DO23690	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.7427
p.T294N	TCGA-A5-A0G1	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.1111
p.T294N	DO42472	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.1111
p.D296N	TCGA-AA-A010	COAD	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.D296N	TCGA-EO-A3B0	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.D296N	DO222815	BTCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.0556
p.D296N	DO219773	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.0556
p.T285I	TCGA-AX-A2HD	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.7078
p.T285I	DO42608	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.7078
p.T275A	TCGA-BR-6452	STAD	TCGA	PISTS	DEG_SPOP_SBC_1	0.1389
p.T275A	DO38404	STAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.1389
p.T275I	TCGA-EB-A44N	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	0.1389
p.T275I	DO47638	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	0.1389
p.L290F	DO8264	COAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.S284C	DO222739	ESCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7541
p.A272V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	0.0556
p.A272V	ACH-000636	Leukemia	CCLE	PISTS	DEG_SPOP_SBC_1	0.0556
p.A272V	RPMI-8402	haematopoietic_and_lymphoid_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.0556
p.I283V	SIDM00570	Gastric Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00961	Ewing's Sarcoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00577	Neuroblastoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00231	Kidney Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00596	Endometrial Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00026	Other Solid Cancers	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM00168	Head and Neck Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.I283V	SIDM01619	Endometrial Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965
p.F278S	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISTS

Degron related mutations and impact score

Drug responses associated with PCDHGB1 mutations

All proteins holding degron of PISTS