DegronMD - P54760(EPHB4)

FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the s... View more >>

GO - Biological processes (BP): angiogenesis [GO:0001525]; axon guidance [GO:0007411]; cell adhesion [GO:0007155]; cell migration involved in sprouting angiogenesis [GO:0002042]; ephrin receptor signaling pathway [GO:0048013]; heart morphogenesis [GO:0003007]; positive regulation of kinase activity [GO:0033674]; protein autophosph... View more >>

GO - Molecular function (MF): ATP binding [GO:0005524]; ephrin receptor activity [GO:0005003]; protein serine/threonine/tyrosine kinase activity [GO:0004712]; transmembrane-ephrin receptor activity [GO:0005005]; transmembrane receptor protein tyrosine kinase activity [GO:0004714]

GO - Cellular component (CC): cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular region [GO:0005576]; integral component of plasma membrane [GO:0005887]; neuron projection [GO:0043005]; plasma membrane [GO:0005886]; receptor complex [GO:0043235]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P977L	TCGA-2W-A8YY	CESC	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.7582
p.P977L	DO223732	CESC	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.7582
p.R495W	DO222864	COCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7523
p.R491Q	ACH-001518	Endometrial/Uterine Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7329
p.G496R	TCGA-10-0931	OV	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6457
p.G496R	DO28631	OV	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6457
p.S964T	ACH-000620	Liver Cancer	CCLE	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation blocking phosphorylation signal	0.5
p.E489K	TCGA-VS-A9U7	CESC	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.E489K	DO219729	CESC	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.E489Q	DO228300	BRCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.E834D	TCGA-V5-AASX	ESCA	TCGA	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2778
p.T487A	DO51504	PACA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.25
p.P983R	SIDM01387	Small Cell Lung Carcinoma	GDSC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.P983R	ACH-000921	Lung Cancer	CCLE	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.P842L	DO222653	MELA	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2222
p.A832V	DO232224	PBCA	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2222
p.P985A	TCGA-A3-3378	KIRC	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.P985T	TCGA-HU-A4GU	STAD	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.P985T	DO47849	STAD	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.Y503D	DO229268	THCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 39 entries

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Kaplan plot for EPHB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPHB4

UniProt ID: P54760

Entrez ID: 2050

Protein name: Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPHB4 in