DegronMD - P54760(EPHB4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G496R	TCGA-10-0931	OV	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6457
p.G496R	DO28631	OV	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.6457
p.P977L	TCGA-2W-A8YY	CESC	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.7582
p.P977L	DO223732	CESC	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation altering degron motif	0.7582
p.P985A	TCGA-A3-3378	KIRC	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.R508P	TCGA-AX-A2H5	UCEC	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.R508P	DO41157	UCEC	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.S848Y	TCGA-FS-A1Z3	SKCM	TCGA	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0556
p.S848Y	DO37635	SKCM	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0556
p.P985T	TCGA-HU-A4GU	STAD	TCGA	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.P985T	DO47849	STAD	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1944
p.Q827E	TCGA-LP-A4AV	CESC	TCGA	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0833
p.Q827E	DO44275	CESC	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0833
p.E834D	TCGA-V5-AASX	ESCA	TCGA	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2778
p.I830T	TCGA-VQ-A8P2	STAD	TCGA	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.1667
p.I830T	DO51761	STAD	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.1667
p.E489K	TCGA-VS-A9U7	CESC	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.E489K	DO219729	CESC	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.E489Q	DO228300	BRCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.3056
p.R495W	DO222864	COCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7523
p.H967N	DO229038	LICA	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1389
p.S481R	DO229045	LICA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0833
p.Q966K	DO229006	LICA	ICGC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.1111
p.P842L	DO222653	MELA	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2222
p.T487A	DO51504	PACA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.25
p.R483W	DO228138	PBCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1389
p.R483W	ACH-000999	Colon/Colorectal Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1389
p.A832V	DO232224	PBCA	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.2222
p.Q827P	DO228582	PRAD	ICGC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0833
p.V482M	DO228640	PRAD	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1111
p.Y503D	DO229268	THCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.1944
p.S848F	SIDM00566	Oral Cavity Carcinoma	GDSC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0556
p.S848F	OSC-19	upper aerodigestive tract	COSMIC	DYR	CBL_MET	836:838	Mutation rewiring degron network	0.0556
p.R508W	SIDM01770	Gastric Carcinoma	GDSC	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.R508W	ACH-000908	Gastric Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation rewiring degron network	0.0556
p.P983R	SIDM01387	Small Cell Lung Carcinoma	GDSC	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.P983R	ACH-000921	Lung Cancer	CCLE	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation rewiring degron network	0.25
p.S964T	ACH-000620	Liver Cancer	CCLE	PGTPGGT	DEG_SCF_FBW7_1	974:980	Mutation blocking phosphorylation signal	0.5
p.R491Q	ACH-001518	Endometrial/Uterine Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	490:498	Mutation altering degron motif	0.7329

Kaplan plot for EPHB4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EPHB4

UniProt ID: P54760

Entrez ID: 2050

Protein name: Ephrin type-B receptor 4 (EC 2.7.10.1) (Hepatoma transmembrane kinase) (Tyrosine-protein kinase TYRO11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EPHB4 in