DegronMD

Uniprot ID: P54760

Source protein: Ephrin type-B receptor 4

Source gene: EPHB4

Class: DEG_APCC_DBOX_1

Location: 490:498

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5424

ASA_SCORE: 65.8444

COIL: 0.3361

CONS_SCORE: 0.5014

DSS_SCORE: 0.3592

HELIX: 0.0081

FCONS_SCORE: 0.993

RIG_SCORE: 0.7703

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G496R	TCGA-10-0931	OV	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	0.6457
p.G496R	DO28631	OV	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.6457
p.R508P	TCGA-AX-A2H5	UCEC	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	0.0556
p.R508P	DO41157	UCEC	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.0556
p.E489K	TCGA-VS-A9U7	CESC	TCGA	NRAELRGLK	DEG_APCC_DBOX_1	0.3056
p.E489K	DO219729	CESC	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.3056
p.E489Q	DO228300	BRCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.3056
p.R495W	DO222864	COCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.7523
p.S481R	DO229045	LICA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.0833
p.T487A	DO51504	PACA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.25
p.R483W	DO228138	PBCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.1389
p.R483W	ACH-000999	Colon/Colorectal Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	0.1389
p.V482M	DO228640	PRAD	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.1111
p.Y503D	DO229268	THCA	ICGC	NRAELRGLK	DEG_APCC_DBOX_1	0.1944
p.R508W	SIDM01770	Gastric Carcinoma	GDSC	NRAELRGLK	DEG_APCC_DBOX_1	0.0556
p.R508W	ACH-000908	Gastric Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	0.0556
p.R491Q	ACH-001518	Endometrial/Uterine Cancer	CCLE	NRAELRGLK	DEG_APCC_DBOX_1	0.7329

Drug responses associated with EPHB4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P208L (No)	GDSC	NVP-BHG712	24.7915
SIDM00926	UNCLASSIFIED\|lung_NSCLC_not_specified	p.P208L (No)	GDSC	EphB4_9721	82.8607
SIDM00688	DLBC\|B_cell_lymphoma	p.P599R (No)	GDSC	NVP-BHG712	1.4382
SIDM00688	DLBC\|B_cell_lymphoma	p.P599R (No)	GDSC	EphB4_9721	96.2861
SIDM00499	PRAD\|prostate	p.T587A (No)	GDSC	NVP-BHG712	8.6488
SIDM00499	PRAD\|prostate	p.T587A (No)	GDSC	EphB4_9721	22.8901
SIDM00683	PRAD\|prostate	p.D576G (No)	GDSC	NVP-BHG712	18.628
SIDM00683	PRAD\|prostate	p.D576G (No)	GDSC	EphB4_9721	7.6034
SIDM00260	STAD\|stomach	p.A800T (No)	GDSC	NVP-BHG712	47.8039
SIDM00260	STAD\|stomach	p.A800T (No)	GDSC	EphB4_9721	4.7232
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.E609Q (No)	GDSC	NVP-BHG712	22.2554
SIDM00953	SCLC\|lung_small_cell_carcinoma	p.E609Q (No)	GDSC	EphB4_9721	139.1172
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V718L (No)	GDSC	NVP-BHG712	290.8897
SIDM00584	UNCLASSIFIED\|osteosarcoma	p.V718L (No)	GDSC	EphB4_9721	4.6668
SIDM00461	LAML\|acute_myeloid_leukaemia	p.C285S (No)	GDSC	NVP-BHG712	2.46
SIDM00461	LAML\|acute_myeloid_leukaemia	p.C285S (No)	GDSC	EphB4_9721	16.5819
SIDM01107	SKCM\|melanoma	p.P36S (No)	GDSC	NVP-BHG712	17.7135
SIDM01107	SKCM\|melanoma	p.P36S (No)	GDSC	EphB4_9721	282.9132
SIDM00566	HNSC\|head_and_neck	p.S848F (No)	GDSC	NVP-BHG712	16.8811
SIDM00566	HNSC\|head_and_neck	p.S848F (No)	GDSC	EphB4_9721	7.1534
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R917Q (No)	GDSC	NVP-BHG712	24.8912
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.R917Q (No)	GDSC	EphB4_9721	39.9437
SIDM00146	BRCA\|breast	p.L21V (No)	GDSC	NVP-BHG712	10.8565
SIDM00146	BRCA\|breast	p.L21V (No)	GDSC	EphB4_9721	17.6442
SIDM00980	STAD\|stomach	p.A645S (No)	GDSC	NVP-BHG712	67.7155
SIDM00980	STAD\|stomach	p.A645S (No)	GDSC	EphB4_9721	8.4323
SIDM01045	UCEC\|endometrium	p.V387L (No)	GDSC	NVP-BHG712	20.5958
SIDM01045	UCEC\|endometrium	p.V387L (No)	GDSC	EphB4_9721	43.0848
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.K635N (No)	GDSC	NVP-BHG712	26.4272
SIDM00313	UNCLASSIFIED\|Hodgkin_lymphoma	p.K635N (No)	GDSC	EphB4_9721	37.3109
SIDM00333	UCEC\|endometrium	p.M185V (No)	GDSC	NVP-BHG712	24.7201
SIDM00333	UCEC\|endometrium	p.M185V (No)	GDSC	EphB4_9721	5.0523
SIDM00442	THCA\|thyroid	p.C285S (No)	GDSC	NVP-BHG712	125.6644
SIDM00217	COREAD\|large_intestine	p.V689I (No)	GDSC	NVP-BHG712	21.2675
SIDM00217	COREAD\|large_intestine	p.V689I (No)	GDSC	EphB4_9721	120.2251
SIDM00217	COREAD\|large_intestine	p.Y308H (No)	GDSC	NVP-BHG712	21.2675
SIDM00217	COREAD\|large_intestine	p.Y308H (No)	GDSC	EphB4_9721	120.2251
SIDM00839	COREAD\|large_intestine	p.R105C (No)	GDSC	NVP-BHG712	13.9956
SIDM00839	COREAD\|large_intestine	p.R105C (No)	GDSC	EphB4_9721	1.0803
SIDM00216	COREAD\|large_intestine	p.V84I (No)	GDSC	NVP-BHG712	9.1503
SIDM00282	COREAD\|large_intestine	p.R105C (No)	GDSC	NVP-BHG712	84.0904
SIDM00282	COREAD\|large_intestine	p.R105C (No)	GDSC	EphB4_9721	25.7759
SIDM00282	COREAD\|large_intestine	p.R102W (No)	GDSC	NVP-BHG712	84.0904
SIDM00282	COREAD\|large_intestine	p.R102W (No)	GDSC	EphB4_9721	25.7759
SIDM00888	MB\|medulloblastoma	p.T356S (No)	GDSC	NVP-BHG712	107.6605
SIDM00888	MB\|medulloblastoma	p.T356S (No)	GDSC	EphB4_9721	12.974
SIDM01000	SKCM\|melanoma	p.C288S (No)	GDSC	NVP-BHG712	5.1555
SIDM01000	SKCM\|melanoma	p.C288S (No)	GDSC	EphB4_9721	14.7807
SIDM01160	BLCA\|bladder	p.V113I (No)	GDSC	NVP-BHG712	87.3257
SIDM01160	BLCA\|bladder	p.V113I (No)	GDSC	EphB4_9721	5.2797
SIDM00660	COREAD\|large_intestine	p.R384fs*26 (No)	GDSC	NVP-BHG712	7.2698
SIDM00660	COREAD\|large_intestine	p.R384fs*26 (No)	GDSC	EphB4_9721	50.0498
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.R360H (No)	GDSC	NVP-BHG712	57.0917
SIDM00116	LUAD\|lung_NSCLC_adenocarcinoma	p.R360H (No)	GDSC	EphB4_9721	15.2147
SIDM00257	NB\|neuroblastoma	p.A863S (No)	GDSC	NVP-BHG712	7.5446
SIDM00257	NB\|neuroblastoma	p.A863S (No)	GDSC	EphB4_9721	1.5291
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.S825N (No)	GDSC	NVP-BHG712	1.5365
SIDM00863	UNCLASSIFIED\|Burkitt_lymphoma	p.S825N (No)	GDSC	EphB4_9721	13.6289
SIDM00534	COREAD\|large_intestine	p.R656Q (No)	GDSC	NVP-BHG712	75.3976
SIDM00534	COREAD\|large_intestine	p.R656Q (No)	GDSC	EphB4_9721	9.6944
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E432D (No)	GDSC	NVP-BHG712	14.0151
SIDM00649	UNCLASSIFIED\|lung_NSCLC_large_cell	p.E432D (No)	GDSC	EphB4_9721	2.4157
SIDM00273	LGG\|glioma	p.A725S (No)	GDSC	NVP-BHG712	14.2668
SIDM00273	LGG\|glioma	p.A725S (No)	GDSC	EphB4_9721	7.2576
SIDM00487	COREAD\|large_intestine	p.S575L (No)	GDSC	NVP-BHG712	12.1612
SIDM00487	COREAD\|large_intestine	p.S575L (No)	GDSC	EphB4_9721	15.7577
SIDM00136	COREAD\|large_intestine	p.T775M (No)	GDSC	NVP-BHG712	4.214
SIDM00136	COREAD\|large_intestine	p.T775M (No)	GDSC	EphB4_9721	4.9735
SIDM00343	GBM\|glioma	p.I878V (No)	GDSC	NVP-BHG712	217.0494
SIDM00343	GBM\|glioma	p.I878V (No)	GDSC	EphB4_9721	18.2192
SIDM00779	COREAD\|large_intestine	p.R923G (No)	GDSC	NVP-BHG712	14.535
SIDM00779	COREAD\|large_intestine	p.R923G (No)	GDSC	EphB4_9721	4.1275
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.G579R (No)	GDSC	NVP-BHG712	19.2967
SIDM01108	LUAD\|lung_NSCLC_adenocarcinoma	p.G579R (No)	GDSC	EphB4_9721	1.1106
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.R889G (No)	GDSC	NVP-BHG712	124.2372
SIDM00806	UNCLASSIFIED\|osteosarcoma	p.R889G (No)	GDSC	EphB4_9721	12.1064
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.R394Q (No)	GDSC	NVP-BHG712	6.3711
SIDM00808	UNCLASSIFIED\|Burkitt_lymphoma	p.R394Q (No)	GDSC	EphB4_9721	12.907
SIDM00837	COREAD\|large_intestine	p.I610T (No)	GDSC	NVP-BHG712	37.0868
SIDM00837	COREAD\|large_intestine	p.I610T (No)	GDSC	EphB4_9721	8.2643
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.T403S (No)	GDSC	NVP-BHG712	9.4917
SIDM01010	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.T403S (No)	GDSC	EphB4_9721	61.4913
SIDM01248	THCA\|thyroid	p.R795Q (No)	GDSC	NVP-BHG712	16.1851

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRAELRGLK

Degron related mutations and impact score

Drug responses associated with EPHB4 mutations

All proteins holding degron of NRAELRGLK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P54760	Ephrin type-B receptor 4	DEG_APCC_DBOX_1	490:498	NRAELRGLK	APC,CDC20,FZR1	0.5424	More...