DegronMD - Q9UIW2(PLXNA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1648D	TCGA-2F-A9KO	BLCA	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation altering degron motif	0.6758
p.R443Q	TCGA-2W-A8YY	CESC	TCGA	DYR	CBL_MET	441:443	Mutation altering degron motif	0.7329
p.R443Q	DO223732	CESC	ICGC	DYR	CBL_MET	441:443	Mutation altering degron motif	0.7329
p.R443Q	SIDM01086	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	441:443	Mutation altering degron motif	0.7329
p.R443Q	RS4-11	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	441:443	Mutation altering degron motif	0.7329
p.R1637H	TCGA-5M-AAT6	COAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2222
p.R1637H	TCGA-AX-A2HA	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2222
p.G1650S	TCGA-A5-A0G2	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2778
p.G1650S	DO41235	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2778
p.A436T	TCGA-A5-A0VP	UCEC	TCGA	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1944
p.R1639H	TCGA-AA-3492	COAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2778
p.R1639H	TCGA-QH-A6X9	LGG	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2778
p.L1314M	TCGA-AA-3663	COAD	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0833
p.L1314M	DO9346	COAD	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0833
p.A438V	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.25
p.R1330W	TCGA-AR-A0U2	BRCA	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	DO228246	BRCA	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	DO5067	BRCA	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	DO233836	GACA	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	SIDM00121	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	SIDM01618	B-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	ACH-000942	Leukemia	CCLE	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	ACH-001738	Leukemia	CCLE	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330W	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R443W	TCGA-CK-4951	COAD	TCGA	DYR	CBL_MET	441:443	Mutation altering degron motif	0.8634
p.R443W	DO10582	COAD	ICGC	DYR	CBL_MET	441:443	Mutation altering degron motif	0.8634
p.G1316S	TCGA-D1-A17H	UCEC	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1389
p.P1320H	TCGA-D3-A2J6	SKCM	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.25
p.P1320H	DO37901	SKCM	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.25
p.D1313V	TCGA-DQ-5629	HNSC	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.R445S	TCGA-EE-A3AD	SKCM	TCGA	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.R445S	DO37707	SKCM	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.T1644M	TCGA-EO-A22U	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation altering degron motif	0.7423
p.R1330L	TCGA-ER-A19N	SKCM	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.R1330L	DO37452	SKCM	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.D1323N	TCGA-EY-A215	UCEC	TCGA	DYR	CBL_MET	1323:1325	Mutation altering degron motif	0.6932
p.G1335V	TCGA-FS-A1ZM	SKCM	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.G1335V	DO37731	SKCM	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.G1318D	TCGA-OR-A5LI	ACC	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1944
p.I1319T	TCGA-VQ-A8PP	STAD	TCGA	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.2222
p.I1319T	DO51774	STAD	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.2222
p.A450T	DO217953	BRCA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1389
p.R433H	DO233259	GACA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1111
p.R433H	DO37419	SKCM	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1111
p.R433H	DO42568	UCEC	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1111
p.L434M	DO233766	GACA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1389
p.R435L	DO228974	LICA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1667
p.R435L	DO229032	LICA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1667
p.S1632I	DO228976	LICA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.5278
p.Q1642H	DO229022	LICA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation altering degron motif	0.7582
p.V437L	DO229035	LICA	ICGC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2222
p.E1329K	DO45448	LUSC	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.2222
p.D1638N	DO51314	PRAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6944
p.P1320S	DO218858	SKCA	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.25
p.H1316N	DO37715	SKCM	ICGC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.1389
p.L1640P	DO43218	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.3056
p.K1650N	DO41211	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2778
p.S1635G	SIDM00987	Thyroid Gland Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6111
p.S1635G	SIDM01203	Other Solid Cancers	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6111
p.S1635G	SIDM01021	Glioblastoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6111
p.S1635G	SIDM00474	Ovarian Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6111
p.S1635G	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation blocking phosphorylation signal	0.6111
p.R445H	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.R445H	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.R445H	ACH-001518	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.R445H	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.2778
p.T1326I	SIDM00217	Colorectal Carcinoma	GDSC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.3056
p.T1326I	ACH-000999	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.3056
p.T1326I	SNU-1040	large intestine	COSMIC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.3056
p.G1335R	SIDM00153	T-Lymphoblastic Leukemia	GDSC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.G1335R	ACH-000964	Leukemia	CCLE	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.R1637C	SIDM00228	Thyroid Gland Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2222
p.R1637C	ACH-000897	Thyroid Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	1641:1648	Mutation rewiring degron network	0.2222
p.D1313Y	SIDM01588	Endometrial Carcinoma	GDSC	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.D1313Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	1323:1325	Mutation rewiring degron network	0.0556
p.G451S	ACH-001367	Neuroblastoma	CCLE	DYR	CBL_MET	441:443	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXNA1

UniProt ID: Q9UIW2

Entrez ID: 5361

Protein name: Plexin-A1 (Semaphorin receptor NOV)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXNA1 in