DegronMD

Uniprot ID: Q9UIW2

Source protein: Plexin-A1

Source gene: PLXNA1

Class: DEG_SCF_FBW7_2

Location: 1641:1648

E3 ligase: FBXW7

DEGRON score: 0.9371

ASA_SCORE: 85.15

COIL: 0.8089

CONS_SCORE: 0.4628

DSS_SCORE: 0.515

HELIX: 0.1076

FCONS_SCORE: 0.8022

RIG_SCORE: 0.6955

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1648D	TCGA-2F-A9KO	BLCA	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.6758
p.R1637H	TCGA-5M-AAT6	COAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1637H	TCGA-AX-A2HA	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.G1650S	TCGA-A5-A0G2	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.G1650S	DO41235	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.R1639H	TCGA-AA-3492	COAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.R1639H	TCGA-QH-A6X9	LGG	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.T1644M	TCGA-EO-A22U	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.7423
p.S1632I	DO228976	LICA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.5278
p.Q1642H	DO229022	LICA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.7582
p.D1638N	DO51314	PRAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.6944
p.L1640P	DO43218	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.3056
p.K1650N	DO41211	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.S1635G	SIDM00987	Thyroid Gland Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1635G	SIDM01203	Other Solid Cancers	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1635G	SIDM01021	Glioblastoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1635G	SIDM00474	Ovarian Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1635G	SIDM01692	T-Cell Non-Hodgkin's Lymphoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.R1637C	SIDM00228	Thyroid Gland Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1637C	ACH-000897	Thyroid Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons