DegronMD - O75051(PLXNA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1629V	TCGA-44-3917	LUAD	TCGA	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.6421
p.G1629V	DO25242	LUAD	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.6421
p.K1656N	TCGA-86-8278	LUAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation substituting flanking lysine	0.1667
p.K1656N	DO26308	LUAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation substituting flanking lysine	0.1667
p.C1097Y	TCGA-94-8491	LUSC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0833
p.C1097Y	DO219174	LUSC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0833
p.S1617F	TCGA-A7-A13E	BRCA	TCGA	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.1944
p.S1617F	DO2659	BRCA	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.1944
p.Y1106C	TCGA-BR-8081	STAD	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5976
p.Y1106C	DO38795	STAD	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5976
p.V1122D	TCGA-DI-A1BU	UCEC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1111
p.V1122D	TCGA-DI-A1BU	UCEC	TCGA	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1389
p.V1122D	DO42023	UCEC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1111
p.V1122D	DO42023	UCEC	ICGC	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1389
p.H1653Y	TCGA-DU-6392	LGG	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.1389
p.H1653Y	DO22237	LGG	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.1389
p.R1115H	TCGA-DU-6392	LGG	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.R1115H	TCGA-ZB-A966	THYM	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.R1115H	DO22237	LGG	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.I1613M	TCGA-E7-A7XN	BLCA	TCGA	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.0833
p.I1613M	DO51878	BLCA	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.0833
p.T1112N	TCGA-EO-A22R	UCEC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5944
p.T1112N	DO42713	UCEC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5944
p.T1628A	TCGA-F7-A624	HNSC	TCGA	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.825
p.T1628A	DO44440	HNSC	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.825
p.G1648W	TCGA-HE-7129	KIRP	TCGA	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2778
p.G1648W	DO20786	KIRP	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2778
p.D1622N	TCGA-HF-A5NB	STAD	TCGA	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.5821
p.D1622N	DO50127	STAD	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation altering degron motif	0.5821
p.L1129F	TCGA-NJ-A4YQ	LUAD	TCGA	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation altering degron motif	0.587
p.L1129F	DO218944	LUAD	ICGC	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation altering degron motif	0.587
p.N1124T	TCGA-RC-A7SK	LIHC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0556
p.N1124T	TCGA-RC-A7SK	LIHC	TCGA	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1944
p.N1124T	DO52314	LIHC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0556
p.N1124T	DO52314	LIHC	ICGC	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1944
p.T1096A	DO233888	GACA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.0556
p.G1648V	DO233903	GACA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2778
p.R1620I	DO228974	LICA	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.2778
p.D1111E	DO228976	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5647
p.D1111E	DO229027	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation altering degron motif	0.5647
p.A1099T	DO228972	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.T1104K	DO229036	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.2778
p.R1635W	DO229264	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2222
p.R1635W	DO229264	THCA	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.2222
p.R1635W	DO229250	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2222
p.R1635W	DO229250	THCA	ICGC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.2222
p.R1635W	ACH-000943	Colon/Colorectal Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.2222
p.R1635W	ACH-000943	Colon/Colorectal Cancer	CCLE	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.2222
p.M1640I	DO229268	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation altering degron motif	0.6507
p.F1121L	SIDM01099	Neuroblastoma	GDSC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.F1121L	SIDM01099	Neuroblastoma	GDSC	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1111
p.F1121L	ACH-000341	Neuroblastoma	CCLE	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.F1121L	ACH-000341	Neuroblastoma	CCLE	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1111
p.F1121L	SK-N-FI	autonomic ganglia	COSMIC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.1389
p.F1121L	SK-N-FI	autonomic ganglia	COSMIC	LLIYND	LIG_APCC_ABBA_1	1129:1134	Mutation rewiring degron network	0.1111
p.V1651M	SIDM01187	Breast Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.1944
p.V1651M	SIDM01749	Osteosarcoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	1639:1646	Mutation rewiring degron network	0.1944
p.Y1621H	SIDM00228	Thyroid Gland Carcinoma	GDSC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.3056
p.R1115C	SIDM01619	Endometrial Carcinoma	GDSC	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.R1115C	ACH-000984	Endometrial/Uterine Cancer	CCLE	YRPGLDTVE	DEG_APCC_DBOX_1	1106:1114	Mutation rewiring degron network	0.3056
p.Y1621C	ACH-000930	Breast Cancer	CCLE	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.3056
p.Y1621C	HCC1569	breast	COSMIC	DSSFRYTGSP	CBL_PTK	1622:1631	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLXNA2

UniProt ID: O75051

Entrez ID: 5362

Protein name: Plexin-A2 (Semaphorin receptor OCT)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLXNA2 in