DegronMD

Uniprot ID: O75051

Source protein: Plexin-A2

Source gene: PLXNA2

Class: LIG_APCC_ABBA_1

Location: 1129:1134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6892

ASA_SCORE: 60.25

COIL: 0.509

CONS_SCORE: 0.352

DSS_SCORE: 0.0453

HELIX: 0.029

FCONS_SCORE: 0.6544

RIG_SCORE: 0.9285

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1122D	TCGA-DI-A1BU	UCEC	TCGA	LLIYND	LIG_APCC_ABBA_1	0.1389
p.V1122D	DO42023	UCEC	ICGC	LLIYND	LIG_APCC_ABBA_1	0.1389
p.L1129F	TCGA-NJ-A4YQ	LUAD	TCGA	LLIYND	LIG_APCC_ABBA_1	0.587
p.L1129F	DO218944	LUAD	ICGC	LLIYND	LIG_APCC_ABBA_1	0.587
p.N1124T	TCGA-RC-A7SK	LIHC	TCGA	LLIYND	LIG_APCC_ABBA_1	0.1944
p.N1124T	DO52314	LIHC	ICGC	LLIYND	LIG_APCC_ABBA_1	0.1944
p.F1121L	SIDM01099	Neuroblastoma	GDSC	LLIYND	LIG_APCC_ABBA_1	0.1111
p.F1121L	ACH-000341	Neuroblastoma	CCLE	LLIYND	LIG_APCC_ABBA_1	0.1111
p.F1121L	SK-N-FI	autonomic_ganglia	COSMIC	LLIYND	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75051	Plexin-A2	LIG_APCC_ABBA_1	1129:1134	LLIYND	APC,CDC20,FZR1	0.6892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons