DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
DSSFRYTGSP
Uniprot ID:
O75051
Source protein:
Plexin-A2
Source gene:
PLXNA2
Class:
CBL_PTK
Location:
1622:1631
E3 ligase:
CBL
DEGRON score:
0.9984
ASA_SCORE:
58.63
COIL:
0.7856
CONS_SCORE:
0.4382
DSS_SCORE:
0.4088
HELIX:
0.0925
FCONS_SCORE:
1.0548
RIG_SCORE:
0.6871
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G1629V
TCGA-44-3917
LUAD
TCGA
DSSFRYTGSP
CBL_PTK
0.6421
p.G1629V
DO25242
LUAD
ICGC
DSSFRYTGSP
CBL_PTK
0.6421
p.S1617F
TCGA-A7-A13E
BRCA
TCGA
DSSFRYTGSP
CBL_PTK
0.1944
p.S1617F
DO2659
BRCA
ICGC
DSSFRYTGSP
CBL_PTK
0.1944
p.I1613M
TCGA-E7-A7XN
BLCA
TCGA
DSSFRYTGSP
CBL_PTK
0.0833
p.I1613M
DO51878
BLCA
ICGC
DSSFRYTGSP
CBL_PTK
0.0833
p.T1628A
TCGA-F7-A624
HNSC
TCGA
DSSFRYTGSP
CBL_PTK
0.825
p.T1628A
DO44440
HNSC
ICGC
DSSFRYTGSP
CBL_PTK
0.825
p.D1622N
TCGA-HF-A5NB
STAD
TCGA
DSSFRYTGSP
CBL_PTK
0.5821
p.D1622N
DO50127
STAD
ICGC
DSSFRYTGSP
CBL_PTK
0.5821
p.R1620I
DO228974
LICA
ICGC
DSSFRYTGSP
CBL_PTK
0.2778
p.R1635W
DO229264
THCA
ICGC
DSSFRYTGSP
CBL_PTK
0.2222
p.R1635W
DO229250
THCA
ICGC
DSSFRYTGSP
CBL_PTK
0.2222
p.R1635W
ACH-000943
Colon/Colorectal Cancer
CCLE
DSSFRYTGSP
CBL_PTK
0.2222
p.Y1621H
SIDM00228
Thyroid Gland Carcinoma
GDSC
DSSFRYTGSP
CBL_PTK
0.3056
p.Y1621C
ACH-000930
Breast Cancer
CCLE
DSSFRYTGSP
CBL_PTK
0.3056
p.Y1621C
HCC1569
breast
COSMIC
DSSFRYTGSP
CBL_PTK
0.3056
Drug responses associated with PLXNA2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSSFRYTGSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75051
Plexin-A2
CBL_PTK
1622:1631
DSSFRYTGSP
CBL
0.9984
More...
