DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSSFRYTGSP
Uniprot ID:
O75051
Source protein:
Plexin-A2
Source gene:
PLXNA2
Class:
CBL_PTK
Location:
1622:1631
E3 ligase:
CBL
DEGRON score:
0.9984
ASA_SCORE:
58.63
COIL:
0.7856
CONS_SCORE:
0.4382
DSS_SCORE:
0.4088
HELIX:
0.0925
FCONS_SCORE:
1.0548
RIG_SCORE:
0.6871
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T1628A
TCGA-F7-A624
HNSC
TCGA
DSSFRYTGSP
CBL_PTK
0.825
p.T1628A
DO44440
HNSC
ICGC
DSSFRYTGSP
CBL_PTK
0.825
p.G1629V
TCGA-44-3917
LUAD
TCGA
DSSFRYTGSP
CBL_PTK
0.6421
p.G1629V
DO25242
LUAD
ICGC
DSSFRYTGSP
CBL_PTK
0.6421
p.D1622N
TCGA-HF-A5NB
STAD
TCGA
DSSFRYTGSP
CBL_PTK
0.5821
p.D1622N
DO50127
STAD
ICGC
DSSFRYTGSP
CBL_PTK
0.5821
p.Y1621H
SIDM00228
Thyroid Gland Carcinoma
GDSC
DSSFRYTGSP
CBL_PTK
0.3056
p.Y1621C
ACH-000930
Breast Cancer
CCLE
DSSFRYTGSP
CBL_PTK
0.3056
p.Y1621C
HCC1569
breast
COSMIC
DSSFRYTGSP
CBL_PTK
0.3056
p.R1620I
DO228974
LICA
ICGC
DSSFRYTGSP
CBL_PTK
0.2778
p.R1635W
DO229264
THCA
ICGC
DSSFRYTGSP
CBL_PTK
0.2222
p.R1635W
DO229250
THCA
ICGC
DSSFRYTGSP
CBL_PTK
0.2222
p.R1635W
ACH-000943
Colon/Colorectal Cancer
CCLE
DSSFRYTGSP
CBL_PTK
0.2222
p.S1617F
TCGA-A7-A13E
BRCA
TCGA
DSSFRYTGSP
CBL_PTK
0.1944
p.S1617F
DO2659
BRCA
ICGC
DSSFRYTGSP
CBL_PTK
0.1944
p.I1613M
TCGA-E7-A7XN
BLCA
TCGA
DSSFRYTGSP
CBL_PTK
0.0833
p.I1613M
DO51878
BLCA
ICGC
DSSFRYTGSP
CBL_PTK
0.0833
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Drug responses associated with PLXNA2 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of DSSFRYTGSP
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O75051
Plexin-A2
CBL_PTK
1622:1631
DSSFRYTGSP
CBL
0.9984
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