DegronMD

Uniprot ID: O75051

Source protein: Plexin-A2

Source gene: PLXNA2

Class: DEG_APCC_DBOX_1

Location: 1106:1114

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6746

ASA_SCORE: 80.5111

COIL: 0.7812

CONS_SCORE: 0.3733

DSS_SCORE: 0.3107

HELIX: 0.0427

FCONS_SCORE: 0.6938

RIG_SCORE: 0.8098

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1097Y	TCGA-94-8491	LUSC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.0833
p.C1097Y	DO219174	LUSC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.0833
p.Y1106C	TCGA-BR-8081	STAD	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.5976
p.Y1106C	DO38795	STAD	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.5976
p.V1122D	TCGA-DI-A1BU	UCEC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.1111
p.V1122D	DO42023	UCEC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.1111
p.R1115H	TCGA-DU-6392	LGG	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.3056
p.R1115H	TCGA-ZB-A966	THYM	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.3056
p.R1115H	DO22237	LGG	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.3056
p.T1112N	TCGA-EO-A22R	UCEC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.5944
p.T1112N	DO42713	UCEC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.5944
p.N1124T	TCGA-RC-A7SK	LIHC	TCGA	YRPGLDTVE	DEG_APCC_DBOX_1	0.0556
p.N1124T	DO52314	LIHC	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.0556
p.T1096A	DO233888	GACA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.0556
p.D1111E	DO228976	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.5647
p.D1111E	DO229027	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.5647
p.A1099T	DO228972	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.1389
p.T1104K	DO229036	LICA	ICGC	YRPGLDTVE	DEG_APCC_DBOX_1	0.2778
p.F1121L	SIDM01099	Neuroblastoma	GDSC	YRPGLDTVE	DEG_APCC_DBOX_1	0.1389
p.F1121L	ACH-000341	Neuroblastoma	CCLE	YRPGLDTVE	DEG_APCC_DBOX_1	0.1389
p.F1121L	SK-N-FI	autonomic_ganglia	COSMIC	YRPGLDTVE	DEG_APCC_DBOX_1	0.1389
p.R1115C	SIDM01619	Endometrial Carcinoma	GDSC	YRPGLDTVE	DEG_APCC_DBOX_1	0.3056
p.R1115C	ACH-000984	Endometrial/Uterine Cancer	CCLE	YRPGLDTVE	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75051	Plexin-A2	DEG_APCC_DBOX_1	1106:1114	YRPGLDTVE	APC,CDC20,FZR1	0.6746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons