DegronMD

Uniprot ID: O75051

Source protein: Plexin-A2

Source gene: PLXNA2

Class: DEG_SCF_FBW7_2

Location: 1639:1646

E3 ligase: FBXW7

DEGRON score: 0.9358

ASA_SCORE: 84.675

COIL: 0.7978

CONS_SCORE: 0.4461

DSS_SCORE: 0.4391

HELIX: 0.0921

FCONS_SCORE: 0.7877

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K1656N	TCGA-86-8278	LUAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.1667
p.K1656N	DO26308	LUAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.1667
p.H1653Y	TCGA-DU-6392	LGG	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.H1653Y	DO22237	LGG	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.G1648W	TCGA-HE-7129	KIRP	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.G1648W	DO20786	KIRP	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.G1648V	DO233903	GACA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.R1635W	DO229264	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635W	DO229250	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635W	ACH-000943	Colon/Colorectal Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.M1640I	DO229268	THCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.6507
p.V1651M	SIDM01187	Breast Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.1944
p.V1651M	SIDM01749	Osteosarcoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons