DegronMD

Uniprot ID: Q9HCM2

Source protein: Plexin-A4

Source gene: PLXNA4

Class: DEG_SCF_FBW7_2

Location: 1639:1646

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 76.6875

COIL: 0.8081

CONS_SCORE: 0.4646

DSS_SCORE: 0.5047

HELIX: 0.1169

FCONS_SCORE: 0.8078

RIG_SCORE: 0.7166

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1648V	TCGA-73-4677	LUAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.G1648V	DO23768	LUAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.D1632N	TCGA-A1-A0SF	BRCA	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.D1632N	DO1342	BRCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.R1635H	TCGA-AA-3680	COAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635H	TCGA-AX-A05Z	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635H	TCGA-CD-A4MG	STAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635H	DO9980	COAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635H	DO48009	STAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.R1635H	DO40884	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2222
p.S1633I	TCGA-B5-A0JY	UCEC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1633I	DO43041	UCEC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.G1648A	TCGA-CG-4462	STAD	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.G1648A	DO38292	STAD	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.L1645V	TCGA-CR-7398	HNSC	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.5654
p.L1645V	DO14782	HNSC	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.5654
p.S1633N	TCGA-EE-A20H	SKCM	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.S1633N	DO37986	SKCM	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.6111
p.L1634F	TCGA-EE-A2MR	SKCM	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.1944
p.L1634F	DO37819	SKCM	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.1944
p.R1637Q	TCGA-FW-A3R5	SKCM	TCGA	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.R1637Q	DO37406	SKCM	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.2778
p.P1643H	DO230323	COCA	ICGC	PMITPDLE	DEG_SCF_FBW7_2	0.7694
p.H1653Q	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.H1653Q	ACH-000638	Lung Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.H1653Q	NCI-H441	lung	COSMIC	PMITPDLE	DEG_SCF_FBW7_2	0.1389
p.V1655A	SIDM00519	Mesothelioma	GDSC	PMITPDLE	DEG_SCF_FBW7_2	0.0833
p.V1655A	ACH-002135	Lung Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	0.0833
p.V1655A	H2869	pleura	COSMIC	PMITPDLE	DEG_SCF_FBW7_2	0.0833
p.R1637W	ACH-001518	Endometrial/Uterine Cancer	CCLE	PMITPDLE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75051	Plexin-A2	DEG_SCF_FBW7_2	1639:1646	PMITPDLE	FBXW7	0.9358	More...
Q9HCM2	Plexin-A4	DEG_SCF_FBW7_2	1639:1646	PMITPDLE	FBXW7	0.9966	More...
Q9UIW2	Plexin-A1	DEG_SCF_FBW7_2	1641:1648	PMITPDLE	FBXW7	0.9371	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PMITPDLE

Degron related mutations and impact score

Drug responses associated with PLXNA4 mutations

All proteins holding degron of PMITPDLE