DegronMD - Q9Y5H2(PCDHGA11)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S180C	TCGA-22-1005	LUSC	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.S180C	DO26632	LUSC	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.R186K	TCGA-64-1677	LUAD	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7237
p.R186K	DO23996	LUAD	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7237
p.R186K	DO49463	PACA	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7237
p.T187M	TCGA-AA-3864	COAD	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.T187M	TCGA-LI-A67I	SARC	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.T187M	DO8490	COAD	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.T187M	DO220201	SARC	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.A190V	TCGA-BR-4257	STAD	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.2222
p.A190V	DO38683	STAD	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.2222
p.R184Q	TCGA-DA-A1IC	SKCM	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7329
p.R184Q	DO37430	SKCM	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7329
p.N176I	TCGA-EO-A3KX	UCEC	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.1944
p.N176I	DO219774	UCEC	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.1944
p.P193S	TCGA-FS-A1ZD	SKCM	TCGA	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.1389
p.P193S	DO37627	SKCM	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.1389
p.P901T	DO233115	GACA	ICGC	DYR	CBL_MET	893:895	Mutation rewiring degron network	0.1667
p.Q172R	DO228947	LICA	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.0833
p.V891M	DO25554	LUAD	ICGC	DYR	CBL_MET	893:895	Mutation rewiring degron network	0.2778
p.V891M	SLVL	haematopoietic and lymphoid tissue	COSMIC	DYR	CBL_MET	893:895	Mutation rewiring degron network	0.2778
p.V898G	DO28089	OV	ICGC	DYR	CBL_MET	893:895	Mutation rewiring degron network	0.25
p.T887A	DO48918	PBCA	ICGC	DYR	CBL_MET	893:895	Mutation rewiring degron network	0.1667
p.S180F	DO232224	PBCA	ICGC	LQLRGR	SCF_FBXL2	181:186	Mutation rewiring degron network	0.3056
p.R895H	DO41871	UCEC	ICGC	DYR	CBL_MET	893:895	Mutation altering degron motif	0.8244
p.R895C	DO42568	UCEC	ICGC	DYR	CBL_MET	893:895	Mutation altering degron motif	0.8301
p.G185D	SIDM02059	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7198
p.G185D	SIDM01278	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7198
p.G185D	ACH-001061	Colon/Colorectal Cancer	CCLE	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.7198
p.R186I	SIDM00837	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.8102
p.R186I	ACH-000958	Colon/Colorectal Cancer	CCLE	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.8102
p.R186I	SW48	large intestine	COSMIC	LQLRGR	SCF_FBXL2	181:186	Mutation altering degron motif	0.8102

Kaplan plot for PCDHGA11 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PCDHGA11

UniProt ID: Q9Y5H2

Entrez ID: 56105

Protein name: Protocadherin gamma-A11 (PCDH-gamma-A11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PCDHGA11 in