DegronMD

Uniprot ID: Q9Y5H2

Source protein: Protocadherin gamma-A11

Source gene: PCDHGA11

Class: SCF_FBXL2

Location: 181:186

E3 ligase: FBXL2

DEGRON score: 0.8001

ASA_SCORE: 55.0333

COIL: 0.2267

CONS_SCORE: 0.516

DSS_SCORE: 0.4721

HELIX: 0.002

FCONS_SCORE: 0.9971

RIG_SCORE: 0.7395

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S180C	TCGA-22-1005	LUSC	TCGA	LQLRGR	SCF_FBXL2	0.3056
p.S180C	DO26632	LUSC	ICGC	LQLRGR	SCF_FBXL2	0.3056
p.R186K	TCGA-64-1677	LUAD	TCGA	LQLRGR	SCF_FBXL2	0.7237
p.R186K	DO23996	LUAD	ICGC	LQLRGR	SCF_FBXL2	0.7237
p.R186K	DO49463	PACA	ICGC	LQLRGR	SCF_FBXL2	0.7237
p.T187M	TCGA-AA-3864	COAD	TCGA	LQLRGR	SCF_FBXL2	0.3056
p.T187M	TCGA-LI-A67I	SARC	TCGA	LQLRGR	SCF_FBXL2	0.3056
p.T187M	DO8490	COAD	ICGC	LQLRGR	SCF_FBXL2	0.3056
p.T187M	DO220201	SARC	ICGC	LQLRGR	SCF_FBXL2	0.3056
p.A190V	TCGA-BR-4257	STAD	TCGA	LQLRGR	SCF_FBXL2	0.2222
p.A190V	DO38683	STAD	ICGC	LQLRGR	SCF_FBXL2	0.2222
p.R184Q	TCGA-DA-A1IC	SKCM	TCGA	LQLRGR	SCF_FBXL2	0.7329
p.R184Q	DO37430	SKCM	ICGC	LQLRGR	SCF_FBXL2	0.7329
p.N176I	TCGA-EO-A3KX	UCEC	TCGA	LQLRGR	SCF_FBXL2	0.1944
p.N176I	DO219774	UCEC	ICGC	LQLRGR	SCF_FBXL2	0.1944
p.P193S	TCGA-FS-A1ZD	SKCM	TCGA	LQLRGR	SCF_FBXL2	0.1389
p.P193S	DO37627	SKCM	ICGC	LQLRGR	SCF_FBXL2	0.1389
p.Q172R	DO228947	LICA	ICGC	LQLRGR	SCF_FBXL2	0.0833
p.S180F	DO232224	PBCA	ICGC	LQLRGR	SCF_FBXL2	0.3056
p.G185D	SIDM02059	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	0.7198
p.G185D	SIDM01278	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	0.7198
p.G185D	ACH-001061	Colon/Colorectal Cancer	CCLE	LQLRGR	SCF_FBXL2	0.7198
p.R186I	SIDM00837	Colorectal Carcinoma	GDSC	LQLRGR	SCF_FBXL2	0.8102
p.R186I	ACH-000958	Colon/Colorectal Cancer	CCLE	LQLRGR	SCF_FBXL2	0.8102
p.R186I	SW48	large_intestine	COSMIC	LQLRGR	SCF_FBXL2	0.8102

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5H2	Protocadherin gamma-A11	SCF_FBXL2	181:186	LQLRGR	FBXL2	0.8001	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons