INTS13
UniProt ID: Q9NVM9
Entrez ID: 55726
Protein name: Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of ...
FUNCTION: Crucial regulator of the mitotic cell cycle and development. At prophase, required for dynein anchoring to the nuclear envelope important for proper centrosome-nucleus coupling. At G2/M phase, may be required for proper spindle formation and execution of cytokinesis. Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing (PubMed:23904267). {ECO:0000269|PubMed:15737938, ECO:0000269|PubMed:23097494, ECO:0000269|PubMed:23904267, ECO:0000305|PubMed:23097494, ECO:0000305|PubMed:23904267}.
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GO - Biological processes (BP):
cell division [GO:0051301]; centrosome localization [GO:0051642]; flagellated sperm motility [GO:0030317]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]...
cell division [GO:0051301]; centrosome localization [GO:0051642]; flagellated sperm motility [GO:0030317]; mitotic spindle organization [GO:0007052]; protein localization to nuclear envelope [GO:0090435]; regulation of fertilization [GO:0080154]; regulation of mitotic cell cycle [GO:0007346]
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GO - Molecular function (MF):
...
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]...
cytoplasm [GO:0005737]; integrator complex [GO:0032039]; intracellular membrane-bounded organelle [GO:0043231]; nuclear body [GO:0016604]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]
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INTS13
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*NOTE: the Kaplan plots were collected from OncoLnc