DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MKIFSE
Uniprot ID:
Q9NVM9
Source protein:
Integrator complex subunit 13
Source gene:
INTS13
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8369
ASA_SCORE:
123.35
COIL:
0.9432
CONS_SCORE:
0.3502
DSS_SCORE:
0.5807
HELIX:
0.0265
FCONS_SCORE:
0.638
RIG_SCORE:
0.7654
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F4C
SIDM00193
Colorectal Carcinoma
GDSC
MKIFSE
LIG_APCC_ABBA_1
0.7108
p.F4C
SNU-81
large_intestine
COSMIC
MKIFSE
LIG_APCC_ABBA_1
0.7108
Drug responses associated with INTS13 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of MKIFSE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NVM9
Integrator complex subunit 13
LIG_APCC_ABBA_1
1:6
MKIFSE
APC,CDC20,FZR1
0.8369
More...