DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
MKIFSE
Uniprot ID:
Q9NVM9
Source protein:
Integrator complex subunit 13
Source gene:
INTS13
Class:
LIG_APCC_ABBA_1
Location:
1:6
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8369
ASA_SCORE:
123.35
COIL:
0.9432
CONS_SCORE:
0.3502
DSS_SCORE:
0.5807
HELIX:
0.0265
FCONS_SCORE:
0.638
RIG_SCORE:
0.7654
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.F4C
SIDM00193
Colorectal Carcinoma
GDSC
MKIFSE
LIG_APCC_ABBA_1
0.7108
p.F4C
SNU-81
large_intestine
COSMIC
MKIFSE
LIG_APCC_ABBA_1
0.7108
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Drug responses associated with INTS13 mutations
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Sample
Cancer
Mutation (In Degron?)
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Drug
IC50
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All proteins holding degron of MKIFSE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NVM9
Integrator complex subunit 13
LIG_APCC_ABBA_1
1:6
MKIFSE
APC,CDC20,FZR1
0.8369
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