DegronMD - Q9UPN3(MACF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2032I	TCGA-05-4410	LUAD	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.2222
p.S1127I	TCGA-55-7907	LUAD	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.2222
p.S1127I	DO25396	LUAD	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.2222
p.R1132P	TCGA-55-8089	LUAD	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7512
p.R1132P	DO23690	LUAD	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7512
p.N3105S	TCGA-61-2109	OV	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.25
p.S560A	TCGA-A5-A0G2	UCEC	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation blocking phosphorylation signal	0.5
p.S560A	DO41235	UCEC	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation blocking phosphorylation signal	0.5
p.K2173T	TCGA-AP-A056	UCEC	TCGA	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.0833
p.A875D	TCGA-AP-A059	UCEC	TCGA	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.25
p.A875D	DO41361	UCEC	ICGC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.25
p.S2047Y	TCGA-AP-A1E0	UCEC	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.25
p.R3122Q	TCGA-AP-A1E0	UCEC	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.1389
p.L2152R	TCGA-B5-A3FA	UCEC	TCGA	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.1667
p.E2136K	TCGA-BS-A0UF	UCEC	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.7022
p.I3107V	TCGA-BS-A0UF	UCEC	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.3056
p.R587Q	TCGA-CD-A4MI	STAD	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.R587Q	DO47717	STAD	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.R587Q	SIDM00472	Ovarian Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.R587Q	ACH-001630	Ovarian Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.R587Q	PEO1	ovary	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.L1131R	TCGA-CV-A45Z	HNSC	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7316
p.L1131R	DO52064	HNSC	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7316
p.E2130G	TCGA-DI-A1NO	UCEC	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.2778
p.S2163C	TCGA-DK-AA6R	BLCA	TCGA	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.7541
p.K2165N	TCGA-DX-A6YV	SARC	TCGA	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.3056
p.S1124C	TCGA-DX-AB2O	SARC	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation blocking phosphorylation signal	0.5833
p.S1124C	DO220083	SARC	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation blocking phosphorylation signal	0.5833
p.P1123L	TCGA-EB-A430	SKCM	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.1111
p.P1123L	DO37906	SKCM	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.1111
p.R566Q	TCGA-EE-A29M	SKCM	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.2222
p.R566Q	DO37404	SKCM	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.2222
p.G1147C	TCGA-EE-A3AD	SKCM	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.1111
p.G1147C	DO37707	SKCM	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.1111
p.L2029F	TCGA-EE-A3JI	SKCM	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1389
p.L2029F	SIDM00578	Neuroblastoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1389
p.L2029F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1389
p.L2029F	SIDM01781	Gastric Carcinoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1389
p.L2029F	NB1	autonomic ganglia	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1389
p.A3116T	TCGA-EM-A3ST	THCA	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.3056
p.P2154H	TCGA-FS-A1ZB	SKCM	TCGA	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.2222
p.V3109I	TCGA-HU-A4H8	STAD	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.7076
p.L2033M	TCGA-IB-7651	PAAD	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.25
p.S3117Y	TCGA-LT-A5Z6	BLCA	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.2778
p.R2134W	TCGA-MX-A5UJ	STAD	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.8634
p.R2134W	SIDM01313	Colorectal Carcinoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.8634
p.H3123Y	TCGA-NH-A5IV	COAD	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.1111
p.F3107L	DO48440	BLCA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.3056
p.E3115Q	DO225367	BRCA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.6744
p.A6308T	DO228483	BRCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO230346	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO229013	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO229016	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO229003	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO229005	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO234205	ESAD	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6308T	DO230542	LUSC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6028
p.A6299T	DO4263	BRCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.25
p.A6299T	DO35725	PBCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.25
p.R2133W	DO222953	BTCA	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.8634
p.K6411N	DO51599	CESC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation blocking ubiquitination signal	0.75
p.D6405G	DO222798	COCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation altering degron motif	0.7198
p.P568S	DO11854	GBM	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.2778
p.V2127I	DO10880	GBM	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.1944
p.S7209C	DO14846	HNSC	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation blocking phosphorylation signal	0.6944
p.P2141S	DO14574	HNSC	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.3056
p.D2152N	DO223269	HNSC	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.1667
p.W6313L	DO20919	KIRP	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.25
p.Q1121H	DO228985	LICA	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.0556
p.C887F	DO229018	LICA	ICGC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.1389
p.C887F	DO229008	LICA	ICGC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.1389
p.E7206D	DO229024	LICA	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.1667
p.C3109F	DO229027	LICA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.5996
p.A6308S	DO229035	LICA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6477
p.V575L	DO229038	LICA	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation altering degron motif	0.5654
p.S6402I	DO229037	LICA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation rewiring degron network	0.25
p.R587L	DO229037	LICA	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.0833
p.S2172F	DO229177	LMS	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation blocking phosphorylation signal	0.5556
p.S3104N	DO23870	LUAD	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.2222
p.G7219C	DO25020	LUAD	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.2778
p.P7224L	DO222843	MELA	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.1389
p.S6402T	DO50727	ORCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation rewiring degron network	0.25
p.A3099T	DO29338	OV	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.0833
p.H2165Q	DO46657	PAAD	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.3056
p.M6309I	DO232761	PBCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.6507
p.G3101E	DO220239	SARC	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.1389
p.S6406C	DO37839	SKCM	ICGC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation altering degron motif	0.7541
p.Q6311K	DO50279	SKCM	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.3056
p.S7222F	DO47419	SKCM	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation blocking phosphorylation signal	0.6389
p.P2161S	DO38099	SKCM	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.6752
p.P2161S	DO41518	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.6752
p.T2174I	DO219784	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.0556
p.G7207D	DO43306	UCEC	ICGC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.1944
p.M6309T	DO52419	UCEC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation altering degron motif	0.7423
p.D2152G	DO41752	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.1667
p.D2154Y	DO41133	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.2222
p.S6300I	DO42673	UCEC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation blocking phosphorylation signal	0.7222
p.P877R	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00454	Rhabdomyosarcoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM01117	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00650	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00793	Burkitt's Lymphoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM01681	Non-Cancerous	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM00760	Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	SIDM01525	Acute Myeloid Leukemia	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877R	TT	thyroid	COSMIC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.A1135T	SIDM00933	Breast Carcinoma	GDSC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7139
p.A1135T	CAL-51	breast	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7139
p.R3101Q	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.1389
p.T562N	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.1111
p.T562N	ACH-000809	Esophageal Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.1111
p.T562N	KYSE-410	oesophagus	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.1111
p.R571W	SIDM00511	Small Cell Lung Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation altering degron motif	0.8634
p.R571W	ACH-000257	Lung Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation altering degron motif	0.8634
p.R571W	COR-L279	lung	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation altering degron motif	0.8634
p.R2134Q	SIDM00081	Melanoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.7329
p.R2134Q	SK-MEL-28	skin	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.7329
p.P877H	SIDM00493	Other Solid Cancers	GDSC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P877H	NCI-H292	lung	COSMIC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.Q2142H	SIDM01451	Pancreatic Carcinoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.2778
p.R7227Q	ACH-000333	Ovarian Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.0556
p.R7227Q	ACH-000482	Lung Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.0556
p.R7227Q	ACH-000721	Breast Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation rewiring degron network	0.0556
p.R2169G	ACH-000493	Liver Cancer	CCLE	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.1944
p.R2169G	SNU-423	liver	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.1944
p.P3108T	ACH-000885	Ovarian Cancer	CCLE	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.7031
p.P3108T	TOV-21G	ovary	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.7031
p.A6295S	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.1389
p.A6295S	AN3-CA	endometrium	COSMIC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.1389
p.P2161L	ACH-000977	lymph node	CCLE	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.7582
p.P2161L	LNCaP-Clone-FGC	prostate	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.7582
p.A2124T	ACH-000994	Endometrial/Uterine Cancer	CCLE	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.1111
p.V2030A	ACH-000999	Colon/Colorectal Cancer	CCLE	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1667
p.V2030A	SNU-1040	large intestine	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1667
p.R3113G	ACH-002659	Colon/Colorectal Cancer	CCLE	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.6457
p.R2164G	SNU-423	liver	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation altering degron motif	0.7568
p.E1149K	SW1573	lung	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.0556
p.A2147S	A204	soft tissue	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.1389
p.A2147S	SK-OV-3	ovary	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.1389
p.R566W	COR-L279	lung	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.2222
p.L1142Q	NCI-H1651	lung	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.25
p.V877I	SNU-407	large intestine	COSMIC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.A6396S	AN3-CA	endometrium	COSMIC	DSGSGS	DEG_SCF_TRCP1_1	6405:6410	Mutation rewiring degron network	0.0833
p.V888I	NCI-H1944	lung	COSMIC	DYR	CBL_MET	878:880	Mutation substituting flanking lysine	0.2222
p.L569S	CW-2	large intestine	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.3056
p.A2147V	KYSE-180	oesophagus	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation rewiring degron network	0.1389
p.A1121G	RL95-2	endometrium	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.0556
p.K2173R	OC-314	ovary	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.0833
p.G2033D	CW-2	large intestine	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.25
p.Q1130H	NCI-H660	prostate	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.3056
p.R582Q	PEO1	ovary	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	570:578	Mutation rewiring degron network	0.2222
p.S3115I	TASK1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.7341
p.E1127G	EN	endometrium	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation rewiring degron network	0.2222
p.A1137T	GP5d	large intestine	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	1131:1139	Mutation altering degron motif	0.7139
p.R7215L	VMRC-LCD	lung	COSMIC	MTPFRS	DEG_SCF_FBW7_1	7212:7217	Mutation altering degron motif	0.8428
p.R6295Q	CCK-81	large intestine	COSMIC	LRSRLEAMN	DEG_APCC_DBOX_1	6302:6310	Mutation rewiring degron network	0.1389
p.T2030A	COLO-684	endometrium	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	2036:2044	Mutation rewiring degron network	0.1667
p.P877L	CHL-1	skin	COSMIC	DYR	CBL_MET	878:880	Mutation rewiring degron network	0.3056
p.P2156L	LNCaP-Clone-FGC	prostate	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation rewiring degron network	0.2778
p.S3115C	TASK1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation altering degron motif	0.7541
p.P3103T	TOV-21G	ovary	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation rewiring degron network	0.1944
p.S3125N	MHH-ES-1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	3108:3115	Mutation substituting flanking lysine	0.1667
p.R2153H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	VETPKKE	DEG_SCF_FBW7_2	2158:2164	Mutation substituting flanking lysine	0.3056
p.Q2140P	SNU-C5	large intestine	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	2132:2140	Mutation altering degron motif	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MACF1

UniProt ID: Q9UPN3

Entrez ID: 23499

Protein name: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (620 kDa actin-binding protein) (ABP620) (Actin cross-linking family protein 7) (Macrophin-1) (Trabeculin-alpha)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MACF1 in