DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_MDM2_SWIB_1

Location: 2036:2044

E3 ligase: MDM2

DEGRON score: 0.9716

ASA_SCORE: 73.4222

COIL: 0.5909

CONS_SCORE: 0.2259

DSS_SCORE: 0.3815

HELIX: 0.0468

FCONS_SCORE: 0.8025

RIG_SCORE: 0.7576

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2032I	TCGA-05-4410	LUAD	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	0.2222
p.S2047Y	TCGA-AP-A1E0	UCEC	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	0.25
p.L2029F	TCGA-EE-A3JI	SKCM	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1389
p.L2029F	SIDM00578	Neuroblastoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1389
p.L2029F	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1389
p.L2029F	SIDM01781	Gastric Carcinoma	GDSC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1389
p.L2029F	NB1	autonomic_ganglia	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1389
p.L2033M	TCGA-IB-7651	PAAD	TCGA	FSSGWTVRL	DEG_MDM2_SWIB_1	0.25
p.V2030A	ACH-000999	Colon/Colorectal Cancer	CCLE	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1667
p.V2030A	SNU-1040	large_intestine	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1667
p.G2033D	CW-2	large_intestine	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.25
p.T2030A	COLO-684	endometrium	COSMIC	FSSGWTVRL	DEG_MDM2_SWIB_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_MDM2_SWIB_1	2036:2044	FSSGWTVRL	MDM2	0.9716	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons