DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_APCC_DBOX_1

Location: 1131:1139

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.827

ASA_SCORE: 53.3667

COIL: 0.0097

CONS_SCORE: 0.3651

DSS_SCORE: 0.2409

HELIX: 0.9878

FCONS_SCORE: 1.1992

RIG_SCORE: 0.8034

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1127I	TCGA-55-7907	LUAD	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.2222
p.S1127I	DO25396	LUAD	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.2222
p.R1132P	TCGA-55-8089	LUAD	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.7512
p.R1132P	DO23690	LUAD	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.7512
p.L1131R	TCGA-CV-A45Z	HNSC	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.7316
p.L1131R	DO52064	HNSC	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.7316
p.S1124C	TCGA-DX-AB2O	SARC	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.5833
p.S1124C	DO220083	SARC	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.5833
p.P1123L	TCGA-EB-A430	SKCM	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.1111
p.P1123L	DO37906	SKCM	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.1111
p.G1147C	TCGA-EE-A3AD	SKCM	TCGA	LRSELNLLV	DEG_APCC_DBOX_1	0.1111
p.G1147C	DO37707	SKCM	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.1111
p.Q1121H	DO228985	LICA	ICGC	LRSELNLLV	DEG_APCC_DBOX_1	0.0556
p.A1135T	SIDM00933	Breast Carcinoma	GDSC	LRSELNLLV	DEG_APCC_DBOX_1	0.7139
p.A1135T	CAL-51	breast	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.7139
p.E1149K	SW1573	lung	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.0556
p.L1142Q	NCI-H1651	lung	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.25
p.A1121G	RL95-2	endometrium	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.0556
p.Q1130H	NCI-H660	prostate	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.3056
p.E1127G	EN	endometrium	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.2222
p.A1137T	GP5d	large_intestine	COSMIC	LRSELNLLV	DEG_APCC_DBOX_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_APCC_DBOX_1	1131:1139	LRSELNLLV	APC,CDC20,FZR1	0.827	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons