DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_SCF_FBW7_2

Location: 2158:2164

E3 ligase: FBXW7

DEGRON score: 0.9141

ASA_SCORE: 94.7571

COIL: 0.6891

CONS_SCORE: 0.2722

DSS_SCORE: 0.4921

HELIX: 0.1331

FCONS_SCORE: 0.9038

RIG_SCORE: 0.722

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2161L	ACH-000977	lymph_node	CCLE	VETPKKE	DEG_SCF_FBW7_2	0.7582
p.P2161L	LNCaP-Clone-FGC	prostate	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.7582
p.R2164G	SNU-423	liver	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.7568
p.S2163C	TCGA-DK-AA6R	BLCA	TCGA	VETPKKE	DEG_SCF_FBW7_2	0.7541
p.P2161S	DO38099	SKCM	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.6752
p.P2161S	DO41518	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.6752
p.S2172F	DO229177	LMS	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.5556
p.K2165N	TCGA-DX-A6YV	SARC	TCGA	VETPKKE	DEG_SCF_FBW7_2	0.3056
p.H2165Q	DO46657	PAAD	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.3056
p.R2153H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.3056
p.P2156L	LNCaP-Clone-FGC	prostate	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.2778
p.P2154H	TCGA-FS-A1ZB	SKCM	TCGA	VETPKKE	DEG_SCF_FBW7_2	0.2222
p.D2154Y	DO41133	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.2222
p.R2169G	ACH-000493	Liver Cancer	CCLE	VETPKKE	DEG_SCF_FBW7_2	0.1944
p.R2169G	SNU-423	liver	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.1944
p.L2152R	TCGA-B5-A3FA	UCEC	TCGA	VETPKKE	DEG_SCF_FBW7_2	0.1667
p.D2152N	DO223269	HNSC	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.1667
p.D2152G	DO41752	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.1667
p.K2173T	TCGA-AP-A056	UCEC	TCGA	VETPKKE	DEG_SCF_FBW7_2	0.0833
p.K2173R	OC-314	ovary	COSMIC	VETPKKE	DEG_SCF_FBW7_2	0.0833
p.T2174I	DO219784	UCEC	ICGC	VETPKKE	DEG_SCF_FBW7_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_FBW7_2	2158:2164	VETPKKE	FBXW7	0.9141	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons