DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_SCF_FBW7_1

Location: 7212:7217

E3 ligase: FBXW7

DEGRON score: 0.9648

ASA_SCORE: 76.0833

COIL: 0.7088

CONS_SCORE: 0.3828

DSS_SCORE: 0.7272

HELIX: 0.0263

FCONS_SCORE: 0.8927

RIG_SCORE: 0.6676

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R7215L	VMRC-LCD	lung	COSMIC	MTPFRS	DEG_SCF_FBW7_1	0.8428
p.S7209C	DO14846	HNSC	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.6944
p.S7222F	DO47419	SKCM	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.6389
p.G7219C	DO25020	LUAD	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.2778
p.G7207D	DO43306	UCEC	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.1944
p.E7206D	DO229024	LICA	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.1667
p.P7224L	DO222843	MELA	ICGC	MTPFRS	DEG_SCF_FBW7_1	0.1389
p.R7227Q	ACH-000333	Ovarian Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	0.0556
p.R7227Q	ACH-000482	Lung Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	0.0556
p.R7227Q	ACH-000721	Breast Cancer	CCLE	MTPFRS	DEG_SCF_FBW7_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_FBW7_1	7212:7217	MTPFRS	FBXW7	0.9648	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons