DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_SCF_FBW7_2

Location: 3108:3115

E3 ligase: FBXW7

DEGRON score: 0.9206

ASA_SCORE: 91.075

COIL: 0.8255

CONS_SCORE: 0.2688

DSS_SCORE: 0.5276

HELIX: 0.058

FCONS_SCORE: 0.8909

RIG_SCORE: 0.669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N3105S	TCGA-61-2109	OV	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.25
p.R3122Q	TCGA-AP-A1E0	UCEC	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.1389
p.I3107V	TCGA-BS-A0UF	UCEC	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.3056
p.A3116T	TCGA-EM-A3ST	THCA	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.3056
p.V3109I	TCGA-HU-A4H8	STAD	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.7076
p.S3117Y	TCGA-LT-A5Z6	BLCA	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.2778
p.H3123Y	TCGA-NH-A5IV	COAD	TCGA	PCMTPRPE	DEG_SCF_FBW7_2	0.1111
p.F3107L	DO48440	BLCA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.3056
p.E3115Q	DO225367	BRCA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.6744
p.C3109F	DO229027	LICA	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.5996
p.S3104N	DO23870	LUAD	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.2222
p.A3099T	DO29338	OV	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.0833
p.G3101E	DO220239	SARC	ICGC	PCMTPRPE	DEG_SCF_FBW7_2	0.1389
p.R3101Q	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	PCMTPRPE	DEG_SCF_FBW7_2	0.1389
p.P3108T	ACH-000885	Ovarian Cancer	CCLE	PCMTPRPE	DEG_SCF_FBW7_2	0.7031
p.P3108T	TOV-21G	ovary	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	0.7031
p.R3113G	ACH-002659	Colon/Colorectal Cancer	CCLE	PCMTPRPE	DEG_SCF_FBW7_2	0.6457
p.S3115I	TASK1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	0.7341
p.S3115C	TASK1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	0.7541
p.P3103T	TOV-21G	ovary	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	0.1944
p.S3125N	MHH-ES-1	bone	COSMIC	PCMTPRPE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_FBW7_2	3108:3115	PCMTPRPE	FBXW7	0.9206	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons