DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_APCC_DBOX_1

Location: 2132:2140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6262

ASA_SCORE: 78.4556

COIL: 0.652

CONS_SCORE: 0.2499

DSS_SCORE: 0.4688

HELIX: 0.0253

FCONS_SCORE: 0.9555

RIG_SCORE: 0.7222

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2136K	TCGA-BS-A0UF	UCEC	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	0.7022
p.E2130G	TCGA-DI-A1NO	UCEC	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	0.2778
p.R2134W	TCGA-MX-A5UJ	STAD	TCGA	SRGHLLTIP	DEG_APCC_DBOX_1	0.8634
p.R2134W	SIDM01313	Colorectal Carcinoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	0.8634
p.R2133W	DO222953	BTCA	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	0.8634
p.V2127I	DO10880	GBM	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	0.1944
p.P2141S	DO14574	HNSC	ICGC	SRGHLLTIP	DEG_APCC_DBOX_1	0.3056
p.R2134Q	SIDM00081	Melanoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	0.7329
p.R2134Q	SK-MEL-28	skin	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	0.7329
p.Q2142H	SIDM01451	Pancreatic Carcinoma	GDSC	SRGHLLTIP	DEG_APCC_DBOX_1	0.2778
p.A2124T	ACH-000994	Endometrial/Uterine Cancer	CCLE	SRGHLLTIP	DEG_APCC_DBOX_1	0.1111
p.A2147S	A204	soft_tissue	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	0.1389
p.A2147S	SK-OV-3	ovary	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	0.1389
p.A2147V	KYSE-180	oesophagus	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	0.1389
p.Q2140P	SNU-C5	large_intestine	COSMIC	SRGHLLTIP	DEG_APCC_DBOX_1	0.7035

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_APCC_DBOX_1	2132:2140	SRGHLLTIP	APC,CDC20,FZR1	0.6262	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons