DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_APCC_DBOX_1

Location: 6302:6310

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8159

ASA_SCORE: 64.9333

COIL: 0.0109

CONS_SCORE: 0.4843

DSS_SCORE: 0.396

HELIX: 0.9881

FCONS_SCORE: 1.0106

RIG_SCORE: 0.7252

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A6308T	DO228483	BRCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO230346	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO229013	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO229016	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO229003	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO229005	COCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO234205	ESAD	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6308T	DO230542	LUSC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6028
p.A6299T	DO4263	BRCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.25
p.A6299T	DO35725	PBCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.25
p.W6313L	DO20919	KIRP	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.25
p.A6308S	DO229035	LICA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6477
p.M6309I	DO232761	PBCA	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.6507
p.Q6311K	DO50279	SKCM	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.3056
p.M6309T	DO52419	UCEC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.7423
p.S6300I	DO42673	UCEC	ICGC	LRSRLEAMN	DEG_APCC_DBOX_1	0.7222
p.A6295S	ACH-000940	Endometrial/Uterine Cancer	CCLE	LRSRLEAMN	DEG_APCC_DBOX_1	0.1389
p.A6295S	AN3-CA	endometrium	COSMIC	LRSRLEAMN	DEG_APCC_DBOX_1	0.1389
p.R6295Q	CCK-81	large_intestine	COSMIC	LRSRLEAMN	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_APCC_DBOX_1	6302:6310	LRSRLEAMN	APC,CDC20,FZR1	0.8159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons