DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_SCF_TRCP1_1

Location: 6405:6410

E3 ligase: BTRC

DEGRON score: 0.7925

ASA_SCORE: 76.0833

COIL: 0.7557

CONS_SCORE: 0.3754

DSS_SCORE: 0.4473

HELIX: 0.2415

FCONS_SCORE: 0.9901

RIG_SCORE: 0.5778

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K6411N	DO51599	CESC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.75
p.D6405G	DO222798	COCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.7198
p.S6402I	DO229037	LICA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.25
p.S6402T	DO50727	ORCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.25
p.S6406C	DO37839	SKCM	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.7541
p.A6396S	AN3-CA	endometrium	COSMIC	DSGSGS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSY0	G kinase-anchoring protein 1	DEG_SCF_TRCP1_1	22:27	DSGSGS	BTRC	0.9941	More...
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_TRCP1_1	6405:6410	DSGSGS	BTRC	0.7925	More...
Q9Y3Q8	TSC22 domain family protein 4	DEG_SCF_TRCP1_1	309:314	DSGSGS	BTRC	0.9299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons