DegronMD - Q9Y3Q8(TSC22D4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P140R	TCGA-17-Z001	LUAD	TCGA	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1667
p.G134V	TCGA-41-4097	GBM	TCGA	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.6421
p.G134V	DO11705	GBM	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.6421
p.S306N	TCGA-91-6829	LUAD	TCGA	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation blocking phosphorylation signal	0.6944
p.S306N	DO23564	LUAD	ICGC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation blocking phosphorylation signal	0.6944
p.Q324K	TCGA-BP-4163	KIRC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.0556
p.Q324K	TCGA-QF-A5YS	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.0556
p.Q324K	SIDM01294	Esophageal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.0556
p.Q324K	SIDM01957	Esophageal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.0556
p.S123Y	TCGA-BS-A0UF	UCEC	TCGA	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation blocking phosphorylation signal	0.6944
p.S123Y	DO41488	UCEC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation blocking phosphorylation signal	0.6944
p.E129K	TCGA-CN-6998	HNSC	TCGA	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.591
p.E129K	DO15519	HNSC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.591
p.D308Y	TCGA-K4-A54R	BLCA	TCGA	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.3056
p.S142L	DO225215	BRCA	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1111
p.S142L	DO227836	BRCA	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1111
p.E323K	DO37074	READ	ICGC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.0833
p.L124S	DO219954	SARC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2778
p.D308N	SIDM01090	Colorectal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.3056
p.D308N	SIDM00027	Kidney Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.3056
p.D308N	SIDM01316	Ewing's Sarcoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	309:314	Mutation rewiring degron network	0.3056
p.R127K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7237
p.R127K	EMC-BAC-1	lung	COSMIC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation altering degron motif	0.7237
p.P138S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2222
p.P141L	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.1389
p.A136V	ACH-000984	Endometrial/Uterine Cancer	CCLE	SRLELASLG	DEG_APCC_DBOX_1	126:134	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TSC22D4

UniProt ID: Q9Y3Q8

Entrez ID: 81628

Protein name: TSC22 domain family protein 4 (TSC22-related-inducible leucine zipper protein 2) (Tsc-22-like protein THG-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TSC22D4 in