DegronMD

Uniprot ID: Q9Y3Q8

Source protein: TSC22 domain family protein 4

Source gene: TSC22D4

Class: DEG_SCF_TRCP1_1

Location: 309:314

E3 ligase: BTRC

DEGRON score: 0.9299

ASA_SCORE: 52.7667

COIL: 0.8163

CONS_SCORE: 0.4247

DSS_SCORE: 0.4001

HELIX: 0.1138

FCONS_SCORE: 0.8148

RIG_SCORE: 0.6107

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S306N	TCGA-91-6829	LUAD	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.6944
p.S306N	DO23564	LUAD	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.6944
p.Q324K	TCGA-BP-4163	KIRC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.Q324K	TCGA-QF-A5YS	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.Q324K	SIDM01294	Esophageal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.Q324K	SIDM01957	Esophageal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.D308Y	TCGA-K4-A54R	BLCA	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.3056
p.E323K	DO37074	READ	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.0833
p.D308N	SIDM01090	Colorectal Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.3056
p.D308N	SIDM00027	Kidney Carcinoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.3056
p.D308N	SIDM01316	Ewing's Sarcoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSY0	G kinase-anchoring protein 1	DEG_SCF_TRCP1_1	22:27	DSGSGS	BTRC	0.9941	More...
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_TRCP1_1	6405:6410	DSGSGS	BTRC	0.7925	More...
Q9Y3Q8	TSC22 domain family protein 4	DEG_SCF_TRCP1_1	309:314	DSGSGS	BTRC	0.9299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons