DegronMD - Q5VSY0(GKAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S14F	TCGA-63-5128	LUSC	TCGA	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6871
p.S14F	DO27255	LUSC	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.6871
p.G36C	TCGA-AJ-A3EL	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0833
p.G36C	DO41542	UCEC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0833
p.K35N	TCGA-DF-A2KU	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation substituting flanking lysine	0.2222
p.K35N	DO223286	UCEC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation substituting flanking lysine	0.2222
p.A13T	DO230347	COCA	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.3056
p.A13T	DO230347	COCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0833
p.T11N	DO229031	LICA	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation rewiring degron network	0.25
p.L18M	SIDM00683	Prostate Carcinoma	GDSC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.711
p.L18M	ACH-000977	lymph node	CCLE	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.711
p.L18M	LNCaP-Clone-FGC	prostate	COSMIC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation altering degron motif	0.711
p.R37Q	SIDM00149	Melanoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0556
p.R37Q	ACH-000750	Skin Cancer	CCLE	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0556
p.R37Q	LOXIMVI	skin	COSMIC	DSGSGS	DEG_SCF_TRCP1_1	22:27	Mutation rewiring degron network	0.0556
p.V9L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6389
p.V9I	ACH-001061	Colon/Colorectal Cancer	CCLE	SRFALLQVD	DEG_APCC_DBOX_1	14:22	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for GKAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GKAP1

UniProt ID: Q5VSY0

Entrez ID: 80318

Protein name: G kinase-anchoring protein 1 (cGMP-dependent protein kinase-anchoring protein of 42 kDa)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GKAP1 in