DegronMD

Uniprot ID: Q5VSY0

Source protein: G kinase-anchoring protein 1

Source gene: GKAP1

Class: DEG_SCF_TRCP1_1

Location: 22:27

E3 ligase: BTRC

DEGRON score: 0.9941

ASA_SCORE: 67.6

COIL: 0.9082

CONS_SCORE: 0.5166

DSS_SCORE: 0.5875

HELIX: 0.0287

FCONS_SCORE: 0.9963

RIG_SCORE: 0.5756

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G36C	TCGA-AJ-A3EL	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.0833
p.G36C	DO41542	UCEC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.0833
p.K35N	TCGA-DF-A2KU	UCEC	TCGA	DSGSGS	DEG_SCF_TRCP1_1	0.2222
p.K35N	DO223286	UCEC	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.2222
p.A13T	DO230347	COCA	ICGC	DSGSGS	DEG_SCF_TRCP1_1	0.0833
p.R37Q	SIDM00149	Melanoma	GDSC	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.R37Q	ACH-000750	Skin Cancer	CCLE	DSGSGS	DEG_SCF_TRCP1_1	0.0556
p.R37Q	LOXIMVI	skin	COSMIC	DSGSGS	DEG_SCF_TRCP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSY0	G kinase-anchoring protein 1	DEG_SCF_TRCP1_1	22:27	DSGSGS	BTRC	0.9941	More...
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_SCF_TRCP1_1	6405:6410	DSGSGS	BTRC	0.7925	More...
Q9Y3Q8	TSC22 domain family protein 4	DEG_SCF_TRCP1_1	309:314	DSGSGS	BTRC	0.9299	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons