DegronMD

Uniprot ID: Q5VSY0

Source protein: G kinase-anchoring protein 1

Source gene: GKAP1

Class: DEG_APCC_DBOX_1

Location: 14:22

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9352

ASA_SCORE: 41.2111

COIL: 0.4602

CONS_SCORE: 0.6547

DSS_SCORE: 0.4759

HELIX: 0.0446

FCONS_SCORE: 1.4787

RIG_SCORE: 0.7722

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L18M	SIDM00683	Prostate Carcinoma	GDSC	SRFALLQVD	DEG_APCC_DBOX_1	0.711
p.L18M	ACH-000977	lymph_node	CCLE	SRFALLQVD	DEG_APCC_DBOX_1	0.711
p.L18M	LNCaP-Clone-FGC	prostate	COSMIC	SRFALLQVD	DEG_APCC_DBOX_1	0.711
p.S14F	TCGA-63-5128	LUSC	TCGA	SRFALLQVD	DEG_APCC_DBOX_1	0.6871
p.S14F	DO27255	LUSC	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	0.6871
p.V9L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	SRFALLQVD	DEG_APCC_DBOX_1	0.6389
p.V9I	ACH-001061	Colon/Colorectal Cancer	CCLE	SRFALLQVD	DEG_APCC_DBOX_1	0.6389
p.A13T	DO230347	COCA	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	0.3056
p.T11N	DO229031	LICA	ICGC	SRFALLQVD	DEG_APCC_DBOX_1	0.25

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VSY0	G kinase-anchoring protein 1	DEG_APCC_DBOX_1	14:22	SRFALLQVD	APC,CDC20,FZR1	0.9352	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons