DegronMD

Uniprot ID: Q9Y3Q8

Source protein: TSC22 domain family protein 4

Source gene: TSC22D4

Class: DEG_APCC_DBOX_1

Location: 126:134

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8265

ASA_SCORE: 74.9556

COIL: 0.4931

CONS_SCORE: 0.439

DSS_SCORE: 0.4958

HELIX: 0.4566

FCONS_SCORE: 0.9612

RIG_SCORE: 0.7339

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P140R	TCGA-17-Z001	LUAD	TCGA	SRLELASLG	DEG_APCC_DBOX_1	0.1667
p.G134V	TCGA-41-4097	GBM	TCGA	SRLELASLG	DEG_APCC_DBOX_1	0.6421
p.G134V	DO11705	GBM	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.6421
p.S123Y	TCGA-BS-A0UF	UCEC	TCGA	SRLELASLG	DEG_APCC_DBOX_1	0.6944
p.S123Y	DO41488	UCEC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.6944
p.E129K	TCGA-CN-6998	HNSC	TCGA	SRLELASLG	DEG_APCC_DBOX_1	0.591
p.E129K	DO15519	HNSC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.591
p.S142L	DO225215	BRCA	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.1111
p.S142L	DO227836	BRCA	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.1111
p.L124S	DO219954	SARC	ICGC	SRLELASLG	DEG_APCC_DBOX_1	0.2778
p.R127K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SRLELASLG	DEG_APCC_DBOX_1	0.7237
p.R127K	EMC-BAC-1	lung	COSMIC	SRLELASLG	DEG_APCC_DBOX_1	0.7237
p.P138S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRLELASLG	DEG_APCC_DBOX_1	0.2222
p.P141L	ACH-000974	Endometrial/Uterine Cancer	CCLE	SRLELASLG	DEG_APCC_DBOX_1	0.1389
p.A136V	ACH-000984	Endometrial/Uterine Cancer	CCLE	SRLELASLG	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y3Q8	TSC22 domain family protein 4	DEG_APCC_DBOX_1	126:134	SRLELASLG	APC,CDC20,FZR1	0.8265	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons