DegronMD

Uniprot ID: Q9UPN3

Source protein: Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

Source gene: MACF1

Class: DEG_APCC_DBOX_1

Location: 570:578

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.83

ASA_SCORE: 71.7444

COIL: 0.2132

CONS_SCORE: 0.2879

DSS_SCORE: 0.3454

HELIX: 0.7768

FCONS_SCORE: 0.8976

RIG_SCORE: 0.8017

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R571W	SIDM00511	Small Cell Lung Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	0.8634
p.R571W	ACH-000257	Lung Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	0.8634
p.R571W	COR-L279	lung	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.8634
p.V575L	DO229038	LICA	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.5654
p.S560A	TCGA-A5-A0G2	UCEC	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	0.5
p.S560A	DO41235	UCEC	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.5
p.L569S	CW-2	large_intestine	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.3056
p.P568S	DO11854	GBM	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.2778
p.R566Q	TCGA-EE-A29M	SKCM	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	0.2222
p.R566Q	DO37404	SKCM	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.2222
p.R566W	COR-L279	lung	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.2222
p.R582Q	PEO1	ovary	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.2222
p.T562N	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	0.1111
p.T562N	ACH-000809	Esophageal Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	0.1111
p.T562N	KYSE-410	oesophagus	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.1111
p.R587Q	TCGA-CD-A4MI	STAD	TCGA	TRAELVAIS	DEG_APCC_DBOX_1	0.0833
p.R587Q	DO47717	STAD	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.0833
p.R587Q	SIDM00472	Ovarian Carcinoma	GDSC	TRAELVAIS	DEG_APCC_DBOX_1	0.0833
p.R587Q	ACH-001630	Ovarian Cancer	CCLE	TRAELVAIS	DEG_APCC_DBOX_1	0.0833
p.R587Q	PEO1	ovary	COSMIC	TRAELVAIS	DEG_APCC_DBOX_1	0.0833
p.R587L	DO229037	LICA	ICGC	TRAELVAIS	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	DEG_APCC_DBOX_1	570:578	TRAELVAIS	APC,CDC20,FZR1	0.83	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons