DegronMD - O00629(KPNA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D63Y	TCGA-A5-A0G2	UCEC	TCGA	DYR	CBL_MET	65:67	Mutation rewiring degron network	0.2778
p.D63Y	DO41235	UCEC	ICGC	DYR	CBL_MET	65:67	Mutation rewiring degron network	0.2778
p.G504A	TCGA-CN-6992	HNSC	TCGA	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2222
p.G504A	DO14606	HNSC	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2222
p.I501M	TCGA-FD-A3SN	BLCA	TCGA	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.I501M	DO490	BLCA	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.3056
p.V68G	TCGA-FI-A2D0	UCEC	TCGA	DYR	CBL_MET	65:67	Mutation rewiring degron network	0.3056
p.V68G	DO43891	UCEC	ICGC	DYR	CBL_MET	65:67	Mutation rewiring degron network	0.3056
p.P498S	TCGA-GF-A6C9	SKCM	TCGA	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation altering degron motif	0.6752
p.P498S	DO51254	SKCM	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation altering degron motif	0.6752
p.S510L	TCGA-Z2-A8RT	SKCM	TCGA	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.S510L	DO51301	SKCM	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.0556
p.Q502K	DO229029	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2778
p.G504R	DO229054	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.2222
p.T505K	DO229009	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation rewiring degron network	0.1944
p.D493G	SIDM00653	Small Cell Lung Carcinoma	GDSC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation altering degron motif	0.7198
p.D493G	ACH-000514	Lung Cancer	CCLE	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation altering degron motif	0.7198
p.D493G	NCI-H1092	lung	COSMIC	DEDPSLVPEA	DEG_COP1_1	491:500	Mutation altering degron motif	0.7198

Kaplan plot for KPNA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KPNA4

UniProt ID: O00629

Entrez ID: 3840

Protein name: Importin subunit alpha-3 (Importin alpha Q1) (Qip1) (Karyopherin subunit alpha-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KPNA4 in