DegronMD

Uniprot ID: O00629

Source protein: Importin subunit alpha-3

Source gene: KPNA4

Class: DEG_COP1_1

Location: 491:500

E3 ligase: COP1

DEGRON score: 0.9902

ASA_SCORE: 78.09

COIL: 0.8243

CONS_SCORE: 0.3146

DSS_SCORE: 0.4982

HELIX: 0.1333

FCONS_SCORE: 0.7853

RIG_SCORE: 0.7807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G504A	TCGA-CN-6992	HNSC	TCGA	DEDPSLVPEA	DEG_COP1_1	0.2222
p.G504A	DO14606	HNSC	ICGC	DEDPSLVPEA	DEG_COP1_1	0.2222
p.I501M	TCGA-FD-A3SN	BLCA	TCGA	DEDPSLVPEA	DEG_COP1_1	0.3056
p.I501M	DO490	BLCA	ICGC	DEDPSLVPEA	DEG_COP1_1	0.3056
p.P498S	TCGA-GF-A6C9	SKCM	TCGA	DEDPSLVPEA	DEG_COP1_1	0.6752
p.P498S	DO51254	SKCM	ICGC	DEDPSLVPEA	DEG_COP1_1	0.6752
p.S510L	TCGA-Z2-A8RT	SKCM	TCGA	DEDPSLVPEA	DEG_COP1_1	0.0556
p.S510L	DO51301	SKCM	ICGC	DEDPSLVPEA	DEG_COP1_1	0.0556
p.Q502K	DO229029	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	0.2778
p.G504R	DO229054	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	0.2222
p.T505K	DO229009	LICA	ICGC	DEDPSLVPEA	DEG_COP1_1	0.1944
p.D493G	SIDM00653	Small Cell Lung Carcinoma	GDSC	DEDPSLVPEA	DEG_COP1_1	0.7198
p.D493G	ACH-000514	Lung Cancer	CCLE	DEDPSLVPEA	DEG_COP1_1	0.7198
p.D493G	NCI-H1092	lung	COSMIC	DEDPSLVPEA	DEG_COP1_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00629	Importin subunit alpha-3	DEG_COP1_1	491:500	DEDPSLVPEA	COP1	0.9902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons