DegronMD

Uniprot ID: P08581

Source protein: Hepatocyte growth factor receptor

Source gene: MET

Class: CBL_MET

Location: 1002:1004

E3 ligase: CBL

DEGRON score: 0.9838

ASA_SCORE: 70.6333

COIL: 0.5593

CONS_SCORE: 0.5428

DSS_SCORE: 0.4969

HELIX: 0.135

FCONS_SCORE: 1.1311

RIG_SCORE: 0.7772

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R992T	TCGA-AC-A23H	BRCA	TCGA	DYR	CBL_MET	0.5
p.V1014I	TCGA-D3-A2JN	SKCM	TCGA	DYR	CBL_MET	0.0556
p.E1012K	TCGA-EE-A2GM	SKCM	TCGA	DYR	CBL_MET	0.1111
p.R1000M	TCGA-EY-A215	UCEC	TCGA	DYR	CBL_MET	0.7222
p.D1002N	DO224685	COCA	ICGC	DYR	CBL_MET	0.6932
p.M995I	DO52450	COCA	ICGC	DYR	CBL_MET	0.1389
p.M995I	DO35747	PBCA	ICGC	DYR	CBL_MET	0.1389
p.E994K	DO220855	MELA	ICGC	DYR	CBL_MET	0.1111
p.E994K	DO37555	SKCM	ICGC	DYR	CBL_MET	0.1111
p.P1008S	DO222557	MELA	ICGC	DYR	CBL_MET	0.2222
p.D1002G	DO49203	PACA	ICGC	DYR	CBL_MET	0.7198
p.R1004Q	DO232630	PBCA	ICGC	DYR	CBL_MET	0.7329
p.R1004Q	DO43106	UCEC	ICGC	DYR	CBL_MET	0.7329
p.N1014S	DO37018	READ	ICGC	DYR	CBL_MET	0.0556
p.P1013S	DO37487	SKCM	ICGC	DYR	CBL_MET	0.0833
p.V996I	DO47590	SKCM	ICGC	DYR	CBL_MET	0.1667
p.V1007I	SIDM00477	Esophageal Carcinoma	GDSC	DYR	CBL_MET	0.25
p.V1007I	ACH-000383	Esophageal Cancer	CCLE	DYR	CBL_MET	0.25
p.V1007I	TE-9	oesophagus	COSMIC	DYR	CBL_MET	0.25
p.V1007I	OE33	oesophagus	COSMIC	DYR	CBL_MET	0.25
p.P1009S	SIDM00279	Gastric Carcinoma	GDSC	DYR	CBL_MET	0.1944
p.P1009S	ACH-000225	Gastric Cancer	CCLE	DYR	CBL_MET	0.1944
p.P1009S	ECC12	stomach	COSMIC	DYR	CBL_MET	0.1944

Drug responses associated with MET mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
ACH-000348	Skin Cancer	p.T17I (No)	CCLE	PHA-665752	8
ACH-000348	Skin Cancer	p.T17I (No)	CCLE	PF2341066	4.2529
ACH-000007	Colon/Colorectal Cancer	p.E34K (No)	CCLE	PHA-665752	8
ACH-000007	Colon/Colorectal Cancer	p.E34K (No)	CCLE	PF2341066	7.2532
ACH-000985	Colon/Colorectal Cancer	p.T86I (No)	CCLE	PHA-665752	8
ACH-000985	Colon/Colorectal Cancer	p.T86I (No)	CCLE	PF2341066	8
ACH-000988	Endometrial/Uterine Cancer	p.S135N (No)	CCLE	PHA-665752	8
ACH-000988	Endometrial/Uterine Cancer	p.S135N (No)	CCLE	PF2341066	8
ACH-000995	Leukemia	p.H159R (No)	CCLE	PHA-665752	4.2212
ACH-000995	Leukemia	p.H159R (No)	CCLE	PF2341066	1.6869
ACH-000953	Leukemia	p.R191W (No)	CCLE	PHA-665752	8
ACH-000953	Leukemia	p.R191W (No)	CCLE	PF2341066	8
ACH-000652	Pancreatic Cancer	p.T200A (No)	CCLE	PHA-665752	7.3654
ACH-000652	Pancreatic Cancer	p.T200A (No)	CCLE	PF2341066	8
ACH-000971	Colon/Colorectal Cancer	p.V237fs (No)	CCLE	PHA-665752	8
ACH-000971	Colon/Colorectal Cancer	p.V237fs (No)	CCLE	PF2341066	7.0497
ACH-001021	Liver Cancer	p.S244Y (No)	CCLE	PHA-665752	8
ACH-001021	Liver Cancer	p.S244Y (No)	CCLE	PF2341066	8
ACH-000253	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PHA-665752	8
ACH-000253	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PF2341066	5.8932
ACH-001039	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PHA-665752	8
ACH-001039	Colon/Colorectal Cancer	p.I333L (No)	CCLE	PF2341066	3.6586
ACH-000940	Endometrial/Uterine Cancer	p.G344R (No)	CCLE	PHA-665752	8
ACH-000940	Endometrial/Uterine Cancer	p.G344R (No)	CCLE	PF2341066	8
ACH-001187	Fibroblast	p.E355K (No)	CCLE	PHA-665752	8
ACH-001187	Fibroblast	p.E355K (No)	CCLE	PF2341066	8
ACH-000987	Skin Cancer	p.P366S (No)	CCLE	PHA-665752	8
ACH-000987	Skin Cancer	p.P366S (No)	CCLE	PF2341066	8
ACH-001306	Thyroid Cancer	p.PDTSEKF401fs (No)	CCLE	PHA-665752	8
ACH-001306	Thyroid Cancer	p.PDTSEKF401fs (No)	CCLE	PF2341066	6.2365
ACH-000758	Gastric Cancer	p.G456fs (No)	CCLE	PHA-665752	8
ACH-000758	Gastric Cancer	p.G456fs (No)	CCLE	PF2341066	8
ACH-000931	Skin Cancer	p.P472S (No)	CCLE	PHA-665752	8
ACH-000931	Skin Cancer	p.P472S (No)	CCLE	PF2341066	7.9873
ACH-000931	Skin Cancer	p.E493K (No)	CCLE	PHA-665752	8
ACH-000931	Skin Cancer	p.E493K (No)	CCLE	PF2341066	7.9873
ACH-001024	Skin Cancer	p.E493K (No)	CCLE	PHA-665752	8
ACH-001024	Skin Cancer	p.E493K (No)	CCLE	PF2341066	8
ACH-000583	Lymphoma	p.L530V (No)	CCLE	PHA-665752	8
ACH-000583	Lymphoma	p.L530V (No)	CCLE	PF2341066	8
ACH-000353	Esophageal Cancer	p.K595T (No)	CCLE	PHA-665752	8
ACH-000353	Esophageal Cancer	p.K595T (No)	CCLE	PF2341066	8
ACH-000118	Pancreatic Cancer	p.M636V (No)	CCLE	PHA-665752	8
ACH-000118	Pancreatic Cancer	p.M636V (No)	CCLE	PF2341066	8
ACH-000996	Endometrial/Uterine Cancer	p.F753C (No)	CCLE	PHA-665752	8
ACH-000996	Endometrial/Uterine Cancer	p.F753C (No)	CCLE	PF2341066	8
ACH-001024	Skin Cancer	p.P761S (No)	CCLE	PHA-665752	8
ACH-001024	Skin Cancer	p.P761S (No)	CCLE	PF2341066	8
ACH-000408	Esophageal Cancer	p.E815D (No)	CCLE	PHA-665752	8
ACH-000408	Esophageal Cancer	p.E815D (No)	CCLE	PF2341066	8
ACH-000978	Endometrial/Uterine Cancer	p.G843R (No)	CCLE	PHA-665752	8
ACH-000978	Endometrial/Uterine Cancer	p.G843R (No)	CCLE	PF2341066	8
ACH-000921	Lung Cancer	p.I852F (No)	CCLE	PHA-665752	8
ACH-000921	Lung Cancer	p.I852F (No)	CCLE	PF2341066	8
ACH-000876	Breast Cancer	p.D946H (No)	CCLE	PHA-665752	8
ACH-000876	Breast Cancer	p.D946H (No)	CCLE	PF2341066	8
ACH-000973	Bladder Cancer	p.L967F (No)	CCLE	PHA-665752	8
ACH-000973	Bladder Cancer	p.L967F (No)	CCLE	PF2341066	5.6625
ACH-000988	Endometrial/Uterine Cancer	p.K980K (No)	CCLE	PHA-665752	8
ACH-000988	Endometrial/Uterine Cancer	p.K980K (No)	CCLE	PF2341066	8
ACH-000894	Lung Cancer	p.Y989C (No)	CCLE	PHA-665752	8
ACH-000894	Lung Cancer	p.Y989C (No)	CCLE	PF2341066	8
ACH-000847	Gastric Cancer	p.Y989* (No)	CCLE	PHA-665752	8
ACH-000847	Gastric Cancer	p.Y989* (No)	CCLE	PF2341066	3.3069
ACH-000383	Esophageal Cancer	p.V1007I (Yes)	CCLE	PHA-665752	8
ACH-000383	Esophageal Cancer	p.V1007I (Yes)	CCLE	PF2341066	0.8948
ACH-000878	Lung Cancer	p.L1158F (No)	CCLE	PHA-665752	8
ACH-000878	Lung Cancer	p.L1158F (No)	CCLE	PF2341066	8
ACH-000967	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PHA-665752	8
ACH-000967	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PF2341066	8
ACH-001199	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PHA-665752	8
ACH-001199	Colon/Colorectal Cancer	p.R1166* (No)	CCLE	PF2341066	8
ACH-000980	Lung Cancer	p.L1230L (No)	CCLE	PHA-665752	8
ACH-000980	Lung Cancer	p.L1230L (No)	CCLE	PF2341066	2.5806
ACH-000889	Myeloma	p.D1240N (No)	CCLE	PHA-665752	0.7209
ACH-000889	Myeloma	p.D1240N (No)	CCLE	PF2341066	3.7147
ACH-000995	Leukemia	p.D1328fs (No)	CCLE	PHA-665752	4.2212
ACH-000995	Leukemia	p.D1328fs (No)	CCLE	PF2341066	1.6869
ACH-000851	Lung Cancer	p.A1357V (No)	CCLE	PHA-665752	8
ACH-000851	Lung Cancer	p.A1357V (No)	CCLE	PF2341066	8
ACH-000954	Endometrial/Uterine Cancer	p.V1368D (No)	CCLE	PHA-665752	8
ACH-000954	Endometrial/Uterine Cancer	p.V1368D (No)	CCLE	PF2341066	8
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	PHA-665752	17.2441
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Crizotinib	7.6781
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Cabozantinib	4.4868
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	JNJ38877605	169.2053
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	SU11274	6.9338
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Foretinib	0.3712
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	AZD6094	6.7751
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Crizotinib	6.5122
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Savolitinib	1.191
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.L229fs*1 (No)	GDSC	Foretinib	4.5486
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	PHA-665752	43.8301
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Crizotinib	17.4096
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Cabozantinib	57.8143
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	JNJ38877605	82.0185
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	SU11274	50.4066
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Foretinib	3.9915
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	AZD6094	43.896
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Crizotinib	34.001
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Savolitinib	84.671
SIDM00781	COREAD\|large_intestine	p.R1166* (No)	GDSC	Foretinib	10.275
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Cabozantinib	7.227
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	JNJ38877605	151.0574
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	SU11274	19.8908
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Foretinib	0.3838
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	AZD6094	14.2737
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Crizotinib	2.3355
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Savolitinib	8.7656
SIDM00783	COREAD\|large_intestine	p.L238fs*25 (No)	GDSC	Foretinib	1.7066
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Cabozantinib	54.0325
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	JNJ38877605	81.898
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	SU11274	77.1018
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Foretinib	4.3302
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	AZD6094	23.4378
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Crizotinib	136.77
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Savolitinib	10.24
SIDM00596	UCEC\|endometrium	p.R1166* (No)	GDSC	Foretinib	45.124
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	JNJ38877605	98.2251
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	SU11274	24.7074
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Foretinib	4.5289
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	AZD6094	29.3711
SIDM00534	COREAD\|large_intestine	p.R1188* (No)	GDSC	Crizotinib	3.2086
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Cabozantinib	5.3227
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	JNJ38877605	97.274
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	SU11274	41.8516
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Foretinib	0.3147
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	AZD6094	9.6424
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Crizotinib	25.914
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Savolitinib	3.1951
SIDM00290	STAD\|stomach	p.Y989* (No)	GDSC	Foretinib	0.8175
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	PHA-665752	18.2154
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Crizotinib	8.5771
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Cabozantinib	3.9297
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	JNJ38877605	162.9635
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	SU11274	85.6621
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Foretinib	0.1434
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	AZD6094	15.3475
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Crizotinib	12.867
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Savolitinib	5.0299
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G1260S (No)	GDSC	Foretinib	0.7641
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	PHA-665752	12.3737
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Crizotinib	9.1451
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Cabozantinib	4.964
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	JNJ38877605	42.4686
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	SU11274	7.8059
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Foretinib	0.724
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	AZD6094	8.0594
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Crizotinib	1.3568
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Savolitinib	3.4106
SIDM01102	UNCLASSIFIED\|lymphoid_neoplasm_other	p.G212S (No)	GDSC	Foretinib	2.773
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Cabozantinib	6.895
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	JNJ38877605	26.4521
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	SU11274	30.3242
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.2756
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	AZD6094	18.9843
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Crizotinib	38.845
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Savolitinib	18.894
SIDM00402	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.7175
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Cabozantinib	10.0937
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	JNJ38877605	14.6691
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	SU11274	150.8069
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Foretinib	1.1163
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	AZD6094	41.521
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Crizotinib	9.505
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Savolitinib	16.428
SIDM00533	PAAD\|pancreas	p.M636V (No)	GDSC	Foretinib	6.3346
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Cabozantinib	100.7682
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	JNJ38877605	194.7582
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	SU11274	102.5621
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Foretinib	23.5981
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	AZD6094	43.5956
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Crizotinib	106.09
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Savolitinib	15.218
SIDM00523	SCLC\|lung_small_cell_carcinoma	p.L905_H906delinsY (No)	GDSC	Foretinib	2.6383
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.P472S (No)	GDSC	Foretinib	3.3402
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.E493K (No)	GDSC	Foretinib	3.3402
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Cabozantinib	3.8227
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	JNJ38877605	197.2173
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	SU11274	9.0882
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Foretinib	0.3922
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	AZD6094	21.3644
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Crizotinib	46.901
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Savolitinib	21.387
SIDM01228	SKCM\|melanoma	p.P761S (No)	GDSC	Foretinib	3.3402
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	PHA-665752	31.5811
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Crizotinib	30.7228
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Cabozantinib	13.5506
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	JNJ38877605	230.8433
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	SU11274	22.421
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	1.5327
SIDM00240	CESC\|cervix	p.N375S (No)	GDSC	AZD6094	35.5626
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	Cabozantinib	14.4553
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	JNJ38877605	40.9317
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	SU11274	12.0738
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	Foretinib	0.7951
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	AZD6094	10.8726
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	Savolitinib	16.793
SIDM01164	LGG\|glioma	p.T1010I (Yes)	GDSC	Foretinib	2.177
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	PHA-665752	30.7225
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Crizotinib	29.6672
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Cabozantinib	58.5084
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	JNJ38877605	82.6947
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	SU11274	51.9675
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Foretinib	5.5256
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	AZD6094	7.3676
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Crizotinib	29.866
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Savolitinib	18.265
SIDM00325	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Foretinib	1.8367
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	PHA-665752	30.8511
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Crizotinib	62.9203
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Cabozantinib	19.4088
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	JNJ38877605	139.9312
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	SU11274	148.9845
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Foretinib	5.5441
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	AZD6094	69.2874
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Crizotinib	11.092
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Savolitinib	69.952
SIDM00776	COREAD\|large_intestine	p.T1010I (Yes)	GDSC	Foretinib	4.6565
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	Cabozantinib	14.2225
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	JNJ38877605	26.2341
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	SU11274	50.0633
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	Foretinib	0.4501
SIDM00941	KIRC\|kidney	p.V1238I (No)	GDSC	AZD6094	36.6842
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	Cabozantinib	112.6655
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	JNJ38877605	53.7581
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	SU11274	108.8966
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	Foretinib	112.701
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	AZD6094	40.7749
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	Crizotinib	172.82
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	Savolitinib	91.158
SIDM00678	BLCA\|bladder	p.T1010I (Yes)	GDSC	Foretinib	17.139
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Cabozantinib	13.4877
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	JNJ38877605	62.4457
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	SU11274	53.9688
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Foretinib	1.2467
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	AZD6094	15.9232
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Crizotinib	2.4905
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Savolitinib	15.272
SIDM00826	COREAD\|large_intestine	p.I333L (No)	GDSC	Foretinib	0.8531
SIDM01184	BLCA\|bladder	p.T1010I (Yes)	GDSC	Cabozantinib	22.2417
SIDM01184	BLCA\|bladder	p.T1010I (Yes)	GDSC	JNJ38877605	38.6669
SIDM01184	BLCA\|bladder	p.T1010I (Yes)	GDSC	SU11274	63.5032
SIDM01184	BLCA\|bladder	p.T1010I (Yes)	GDSC	Foretinib	2.6857
SIDM01184	BLCA\|bladder	p.T1010I (Yes)	GDSC	AZD6094	31.0364
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	PHA-665752	5.3858
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	Cabozantinib	10.4373
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	JNJ38877605	66.0368
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	SU11274	4.8221
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	Foretinib	0.3157
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	AZD6094	11.7421
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	Crizotinib	8.707
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	Savolitinib	8.9828
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.T1010I (Yes)	GDSC	Foretinib	0.7013
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	PHA-665752	13.2447
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	1.8356
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Cabozantinib	10.7335
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	JNJ38877605	31.5874
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	SU11274	3.4637
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	0.9615
SIDM00959	LAML\|acute_myeloid_leukaemia	p.N375S (No)	GDSC	AZD6094	13.4189
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	PHA-665752	5.717
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Crizotinib	1.648
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Cabozantinib	2.6324
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	JNJ38877605	49.9928
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	SU11274	4.0892
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Foretinib	0.2939
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	AZD6094	9.3463
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Crizotinib	1.1106
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Savolitinib	8.1805
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.T1010I (Yes)	GDSC	Foretinib	0.3906
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	PHA-665752	14.9238
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Crizotinib	22.2565
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	JNJ38877605	40.747
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	SU11274	25.6952
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Foretinib	5.9943
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	AZD6094	35.4035
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Crizotinib	10.13
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Savolitinib	23.513
SIDM00683	PRAD\|prostate	p.V136I (No)	GDSC	Foretinib	4.473
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	PHA-665752	14.9238
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Crizotinib	22.2565
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Cabozantinib	9.9083
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	JNJ38877605	40.747
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	SU11274	25.6952
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Foretinib	5.9943
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	AZD6094	35.4035
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Crizotinib	10.13
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Savolitinib	23.513
SIDM00683	PRAD\|prostate	p.A954V (No)	GDSC	Foretinib	4.473
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Cabozantinib	23.9587
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	JNJ38877605	146.6178
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	SU11274	206.1226
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Foretinib	7.7813
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	AZD6094	27.235
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Crizotinib	90.38
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Savolitinib	22.229
SIDM00997	THCA\|thyroid	p.N375S (No)	GDSC	Foretinib	3.2236
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	PHA-665752	33.8385
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Crizotinib	17.4477
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Cabozantinib	12.2021
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	JNJ38877605	160.9246
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	SU11274	12.0386
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	1.7957
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	AZD6094	27.6886
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Crizotinib	103.35
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Savolitinib	25.21
SIDM00108	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	4.0544
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Cabozantinib	5.4885
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	JNJ38877605	27.9558
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	SU11274	6.4413
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Foretinib	0.5248
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	AZD6094	19.8039
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Crizotinib	20.782
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Savolitinib	22.481
SIDM00901	UCEC\|endometrium	p.G344R (No)	GDSC	Foretinib	0.5609
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	PHA-665752	22.0483
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Crizotinib	34.0171
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Cabozantinib	1.1593
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	JNJ38877605	49.3913
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	SU11274	9.7661
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Foretinib	0.1594
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	AZD6094	45.7361
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Crizotinib	48.406
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Savolitinib	70.222
SIDM00535	UNCLASSIFIED\|chondrosarcoma	p.N375S (No)	GDSC	Foretinib	1.5884
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	Cabozantinib	77.3759
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	JNJ38877605	28.0349
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	SU11274	92.3357
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	Foretinib	72.3378
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	AZD6094	29.1578
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	Crizotinib	22.919
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	Savolitinib	32.639
SIDM00881	BRCA\|breast	p.T1010I (Yes)	GDSC	Foretinib	9.4038
SIDM00777	COREAD\|large_intestine	p.R976T (No)	GDSC	AZD6094	43.2237
SIDM00777	COREAD\|large_intestine	p.R976T (No)	GDSC	Crizotinib	3.9975
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	PHA-665752	3.8571
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Crizotinib	2.6015
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	JNJ38877605	64.4981
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	SU11274	6.7043
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Foretinib	0.1908
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	AZD6094	21.1495
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Crizotinib	0.8455
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Savolitinib	4.1817
SIDM01007	ALL\|lymphoblastic_leukemia	p.A48T (No)	GDSC	Foretinib	0.4275
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	PHA-665752	3.8571
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Crizotinib	2.6015
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Cabozantinib	1.7755
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	JNJ38877605	64.4981
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	SU11274	6.7043
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Foretinib	0.1908
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	AZD6094	21.1495
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Crizotinib	0.8455
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Savolitinib	4.1817
SIDM01007	ALL\|lymphoblastic_leukemia	p.E157G (No)	GDSC	Foretinib	0.4275
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Cabozantinib	78.0231
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	JNJ38877605	298.4791
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	SU11274	211.4888
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Foretinib	32.5213
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	AZD6094	44.6788
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Crizotinib	464.21
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Savolitinib	18.626
SIDM01174	CESC\|cervix	p.D741N (No)	GDSC	Foretinib	203.12
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	PHA-665752	11.7428
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	11.1196
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Cabozantinib	12.9864
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	JNJ38877605	31.5974
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	SU11274	5.6099
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	1.6641
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	AZD6094	15.8003
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Crizotinib	0.6377
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Savolitinib	9.7025
SIDM00308	LCML\|chronic_myeloid_leukaemia	p.N375S (No)	GDSC	Foretinib	0.0759
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	PHA-665752	32.616
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Crizotinib	29.5319
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Cabozantinib	7.9513
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	JNJ38877605	13.9418
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	SU11274	10.2713
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Foretinib	0.5412
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	AZD6094	16.4311
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Crizotinib	58.325
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Savolitinib	26.475
SIDM00326	ESCA\|oesophagus	p.N375K (No)	GDSC	Foretinib	1.3723
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	PHA-665752	7.1466
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Crizotinib	15.8732
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Cabozantinib	10.286
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	JNJ38877605	142.1628
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	SU11274	14.7813
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	0.956
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	AZD6094	30.3869
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Crizotinib	11.084
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Savolitinib	10.362
SIDM00801	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	1.4889
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	PHA-665752	22.4917
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	16.942
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	57.5912
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	198.0691
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	49.1089
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	1.7568
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	AZD6094	25.9014
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	53.466
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	10.767
SIDM01058	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	10.54
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	PHA-665752	28.1191
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Crizotinib	19.8777
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Cabozantinib	9.8171
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	JNJ38877605	66.1107
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	SU11274	74.043
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Foretinib	0.816
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	AZD6094	36.7306
SIDM00677	COREAD\|large_intestine	p.E34K (No)	GDSC	Crizotinib	2.7835
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	Cabozantinib	8.0025
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	JNJ38877605	21.4235
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	SU11274	24.9994
SIDM00318	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	1.1465
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	16.8316
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	162.1547
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	64.2366
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	0.6811
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	39.7902
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	2.7793
SIDM00214	COREAD\|large_intestine	p.N375S (No)	GDSC	Savolitinib	5.2346
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	Cabozantinib	5.8082
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	JNJ38877605	259.6267
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	SU11274	177.9896
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	Foretinib	0.4439
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	AZD6094	53.6459
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	Crizotinib	49.795
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	Savolitinib	9.108
SIDM00003	SKCM\|melanoma	p.M1I (No)	GDSC	Foretinib	1.6566
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Cabozantinib	16.6294
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	JNJ38877605	148.1743
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	SU11274	36.1074
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	0.9419
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Crizotinib	10.471
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Savolitinib	12.412
SIDM00989	BLCA\|bladder	p.N375S (No)	GDSC	Foretinib	1.6407
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	PHA-665752	12.1954
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Crizotinib	0.3868
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Cabozantinib	4.9456
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	JNJ38877605	73.9387
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	SU11274	16.2419
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Foretinib	0.3863
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	AZD6094	7.9777
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Crizotinib	0.1693
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Savolitinib	1.8082
SIDM00421	UNCLASSIFIED\|anaplastic_large_cell_lymphoma	p.E168D (No)	GDSC	Foretinib	0.4679
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Cabozantinib	109.5301
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	JNJ38877605	226.1958
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	SU11274	222.6518
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Foretinib	111.3259
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	AZD6094	47.0009
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Crizotinib	43.591
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Savolitinib	14.657
SIDM00586	LIHC\|liver	p.N375S (No)	GDSC	Foretinib	1.7111
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Cabozantinib	38.4248
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	JNJ38877605	179.6091
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	SU11274	47.5648
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Foretinib	1.5909
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	AZD6094	23.8301
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Crizotinib	6.9241
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Savolitinib	20.744
SIDM00498	COREAD\|large_intestine	p.S1159L (No)	GDSC	Foretinib	4.9264
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Cabozantinib	82.098
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	JNJ38877605	324.8044
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	SU11274	178.188
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Foretinib	5.1482
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	AZD6094	27.0484
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Crizotinib	214.83
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Savolitinib	12.139
SIDM01237	LIHC\|liver	p.S244Y (No)	GDSC	Foretinib	3.3855
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	PHA-665752	30.2231
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Crizotinib	28.8129
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Cabozantinib	77.2987
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	SU11274	6.9368
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Foretinib	4.2043
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	AZD6094	23.343
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Crizotinib	37.894
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Savolitinib	39.891
SIDM00347	ESCA\|oesophagus	p.E815D (No)	GDSC	Foretinib	31.522
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Cabozantinib	50.7912
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	JNJ38877605	42.4935
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	SU11274	26.9316
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Foretinib	16.2501
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	AZD6094	47.4777
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Crizotinib	251.77
SIDM01186	BRCA\|breast	p.N375S (No)	GDSC	Foretinib	10.065
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	PHA-665752	17.0474
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Crizotinib	10.5192
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Cabozantinib	8.4382
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	JNJ38877605	63.077
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	SU11274	34.7571
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Foretinib	0.619
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	AZD6094	23.578
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Crizotinib	12.701
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Savolitinib	6.0445
SIDM00441	LAML\|acute_myeloid_leukaemia	p.R988C (No)	GDSC	Foretinib	0.3825
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Cabozantinib	11.3765
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	JNJ38877605	338.3443
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	SU11274	71.6667
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Foretinib	1.0216
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	AZD6094	54.831
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Crizotinib	24.898
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Savolitinib	33.146
SIDM01045	UCEC\|endometrium	p.G843R (No)	GDSC	Foretinib	4.4671
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	PHA-665752	66.7199
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	Crizotinib	39.0913
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	Cabozantinib	140.6565
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	JNJ38877605	57.1259
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	SU11274	129.4371
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	Foretinib	9.2771
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	AZD6094	84.2403
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	Savolitinib	115.67
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V13L (No)	GDSC	Foretinib	25.346
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	PHA-665752	66.7199
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Crizotinib	39.0913
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Cabozantinib	140.6565
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	JNJ38877605	57.1259
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	SU11274	129.4371
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Foretinib	9.2771
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	AZD6094	84.2403
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Savolitinib	115.67
SIDM00769	LUAD\|lung_NSCLC_adenocarcinoma	p.V941L (No)	GDSC	Foretinib	25.346
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	PHA-665752	37.2134
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Crizotinib	23.4821
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Cabozantinib	40.6716
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	JNJ38877605	71.5203
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	SU11274	28.0086
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Foretinib	18.5007
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	AZD6094	24.0576
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Savolitinib	18.647
SIDM01121	SCLC\|lung_small_cell_carcinoma	p.R988C (No)	GDSC	Foretinib	1.2106
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	Cabozantinib	111.4519
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	JNJ38877605	25.4352
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	SU11274	12.1493
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	Foretinib	5.9583
SIDM00870	BRCA\|breast	p.D1198H (No)	GDSC	AZD6094	12.7034
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Cabozantinib	14.164
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	JNJ38877605	184.4401
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	SU11274	117.8841
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	1.1658
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	AZD6094	25.9244
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Crizotinib	15.189
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Savolitinib	25.601
SIDM00864	CESC\|cervix	p.N375S (No)	GDSC	Foretinib	8.6334
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Cabozantinib	42.0625
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	JNJ38877605	89.2547
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	SU11274	113.1135
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Foretinib	2.8306
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	AZD6094	19.3171
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Crizotinib	2.7499
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Savolitinib	3.9527
SIDM00333	UCEC\|endometrium	p.S135N (No)	GDSC	Foretinib	7.9407
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	Cabozantinib	58.3136
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	JNJ38877605	195.2903
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	SU11274	78.2183
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	Foretinib	5.6325
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.N375S (No)	GDSC	AZD6094	21.9083
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	PHA-665752	6.2352
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Crizotinib	15.8698
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Cabozantinib	6.7751
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	JNJ38877605	19.4157
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	SU11274	6.2926
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Foretinib	1.6522
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	AZD6094	25.2341
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Crizotinib	28.432
SIDM00249	ESCA\|oesophagus	p.K595T (No)	GDSC	Foretinib	5.2938
SIDM00442	THCA\|thyroid	p.T1010I (Yes)	GDSC	Cabozantinib	10.0378
SIDM00442	THCA\|thyroid	p.T1010I (Yes)	GDSC	JNJ38877605	26.7074
SIDM00442	THCA\|thyroid	p.T1010I (Yes)	GDSC	SU11274	192.7118
SIDM00442	THCA\|thyroid	p.T1010I (Yes)	GDSC	Foretinib	1.8527
SIDM00442	THCA\|thyroid	p.T1010I (Yes)	GDSC	AZD6094	26.5519
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Cabozantinib	127.0251
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	JNJ38877605	189.5152
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	SU11274	182.1535
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Foretinib	145.5108
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	AZD6094	38.8082
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Crizotinib	43.018
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Savolitinib	14.374
SIDM00630	BRCA\|breast	p.D946H (No)	GDSC	Foretinib	3.8585
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	Cabozantinib	24.5353
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	JNJ38877605	94.9108
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	SU11274	15.3413
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	Foretinib	1.3018
SIDM00507	UNCLASSIFIED\|lung_other	p.I583M (No)	GDSC	AZD6094	26.1435
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	JNJ38877605	33.9011
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	SU11274	70.9644
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Foretinib	1.6723
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	AZD6094	56.5171
SIDM00217	COREAD\|large_intestine	p.V122D (No)	GDSC	Crizotinib	8.8254
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	12.0756
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	33.9011
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	70.9644
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	1.6723
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	56.5171
SIDM00217	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	8.8254
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Cabozantinib	3.4852
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	JNJ38877605	32.3061
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	SU11274	67.4527
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Foretinib	0.7064
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	AZD6094	8.1617
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Crizotinib	5.7056
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Savolitinib	6.0149
SIDM00599	UNCLASSIFIED\|osteosarcoma	p.N375S (No)	GDSC	Foretinib	0.4891
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	Cabozantinib	101.0679
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	Foretinib	7.5112
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	AZD6094	15.5579
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	Crizotinib	22.117
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	Savolitinib	6.1202
SIDM00134	UNCLASSIFIED\|lung_NSCLC_large_cell	p.T1010I (Yes)	GDSC	Foretinib	2.6253
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	7.2858
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	36.0032
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	71.3557
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	0.5822
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	AZD6094	12.7073
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	8.4343
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	6.0251
SIDM00323	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	31.947
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	PHA-665752	7.7418
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Crizotinib	3.5629
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Cabozantinib	3.6448
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	JNJ38877605	57.338
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	SU11274	3.8614
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Foretinib	0.3998
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	AZD6094	5.2708
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Savolitinib	8.063
SIDM00403	ALL\|lymphoblastic_T_cell_leukaemia	p.N375S (No)	GDSC	Foretinib	0.3051
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	Cabozantinib	3.2848
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	Foretinib	0.8433
SIDM00050	UNCLASSIFIED\|chondrosarcoma	p.V1289M (No)	GDSC	AZD6094	8.3461
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Cabozantinib	18.8532
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	JNJ38877605	50.6133
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	SU11274	91.9794
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Foretinib	2.3784
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	AZD6094	20.9362
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Crizotinib	94.019
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Savolitinib	19.453
SIDM00512	UNCLASSIFIED\|lung_NSCLC_large_cell	p.N375S (No)	GDSC	Foretinib	1.868
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	PHA-665752	29.2168
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Crizotinib	32.5729
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Cabozantinib	54.3496
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	JNJ38877605	52.4957
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	SU11274	110.6518
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Foretinib	3.4158
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	AZD6094	23.6941
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Crizotinib	99.015
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Savolitinib	22.834
SIDM00768	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.Y989C (No)	GDSC	Foretinib	6.636
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Cabozantinib	1.5311
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	JNJ38877605	9.1087
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	SU11274	34.397
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Foretinib	0.2771
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	AZD6094	3.5895
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Crizotinib	1.8787
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Savolitinib	3.3732
SIDM00477	ESCA\|oesophagus	p.V1007I (Yes)	GDSC	Foretinib	0.6008
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	Cabozantinib	100.1288
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	JNJ38877605	39.5869
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	SU11274	25.2141
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	Foretinib	6.6399
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	AZD6094	59.7521
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	Crizotinib	18.627
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	Savolitinib	20.715
SIDM00479	ESCA\|oesophagus	p.K6N (No)	GDSC	Foretinib	1.9328
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Cabozantinib	3.0756
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	JNJ38877605	32.4827
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	SU11274	19.7909
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Foretinib	0.1601
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	AZD6094	5.6118
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Crizotinib	5.7417
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Savolitinib	1.6239
SIDM00406	DLBC\|B_cell_lymphoma	p.A347T (No)	GDSC	Foretinib	0.8172
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	PHA-665752	6.0873
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Crizotinib	3.5811
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Cabozantinib	7.1762
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	JNJ38877605	61.4805
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	SU11274	21.1492
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	Foretinib	0.9388
SIDM00637	DLBC\|B_cell_lymphoma	p.L530V (No)	GDSC	AZD6094	5.2233
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	PHA-665752	18.1781
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Crizotinib	4.2088
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Cabozantinib	13.9018
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	JNJ38877605	316.0609
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	SU11274	86.1406
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Foretinib	0.8652
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	AZD6094	40.6797
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Crizotinib	5.0632
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Savolitinib	28.266
SIDM00660	COREAD\|large_intestine	p.T86I (No)	GDSC	Foretinib	1.4128
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Cabozantinib	4.05
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	JNJ38877605	59.4448
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	SU11274	25.2081
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Foretinib	0.2489
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	AZD6094	22.804
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Crizotinib	10.725
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Savolitinib	2.9304
SIDM00522	SCLC\|lung_small_cell_carcinoma	p.V910F (No)	GDSC	Foretinib	0.6207
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	PHA-665752	22.6657
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Crizotinib	19.9725
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Cabozantinib	36.5642
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	JNJ38877605	79.4232
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	SU11274	67.0028
SIDM01071	SCLC\|lung_small_cell_carcinoma	p.N375S (No)	GDSC	Foretinib	2.343
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Cabozantinib	10.1738
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	JNJ38877605	39.7508
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	SU11274	101.5713
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	0.856
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	AZD6094	37.4808
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Crizotinib	52.316
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Savolitinib	11.296
SIDM01000	SKCM\|melanoma	p.T1010I (Yes)	GDSC	Foretinib	4.7606
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Cabozantinib	7.3368
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	JNJ38877605	15.0119
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	SU11274	7.0805
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Foretinib	0.7116
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	AZD6094	27.7991
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Crizotinib	41.568
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Savolitinib	37.189
SIDM00587	UNCLASSIFIED\|biliary_tract	p.N375S (No)	GDSC	Foretinib	3.0162
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	23.4835
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	357.5145
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	SU11274	183.0642
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	2.052
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	AZD6094	16.3362
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	129.11
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Savolitinib	26.868
SIDM00501	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	11.505
SIDM00557	NB\|neuroblastoma	p.N375S (No)	GDSC	PHA-665752	26.7249
SIDM00557	NB\|neuroblastoma	p.N375S (No)	GDSC	Crizotinib	1.3516
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	PHA-665752	18.0768
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Crizotinib	17.1487
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Cabozantinib	14.6269
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	JNJ38877605	183.4968
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	SU11274	93.1072
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Foretinib	3.8073
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	AZD6094	21.2787
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Crizotinib	5.464
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Savolitinib	7.8757
SIDM00462	LAML\|acute_myeloid_leukaemia	p.T1010I (Yes)	GDSC	Foretinib	2.3693
SIDM00279	UNCLASSIFIED\|stomach	p.P1009S (Yes)	GDSC	Crizotinib	56.106
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	PHA-665752	9.5729
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Crizotinib	6.3021
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Cabozantinib	12.0551
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	JNJ38877605	40.6479
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	SU11274	4.6568
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Foretinib	0.6156
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	AZD6094	11.3641
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Crizotinib	9.1778
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Savolitinib	6.8091
SIDM01251	UNCLASSIFIED\|lymphoid_neoplasm_other	p.N375S (No)	GDSC	Foretinib	3.6308
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Cabozantinib	52.3382
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	JNJ38877605	30.058
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	SU11274	69.2075
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Foretinib	3.3984
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	AZD6094	59.5529
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Crizotinib	120.8
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Savolitinib	5.5655
SIDM00747	LUAD\|lung_NSCLC_adenocarcinoma	p.R988C (No)	GDSC	Foretinib	3.6788
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	PHA-665752	12.0743
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Crizotinib	20.0046
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Cabozantinib	0.7727
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	JNJ38877605	21.7174
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	SU11274	4.9883
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Foretinib	0.0623
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	AZD6094	14.3024
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Crizotinib	19.514
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Savolitinib	8.9698
SIDM00269	UNCLASSIFIED\|ewings_sarcoma	p.N375S (No)	GDSC	Foretinib	0.6014
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	Cabozantinib	18.0066
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	JNJ38877605	14.5893
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	SU11274	26.5801
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	Foretinib	0.7353
SIDM00819	KIRC\|kidney	p.V136I (No)	GDSC	AZD6094	12.3475
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Cabozantinib	67.7731
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	JNJ38877605	62.5579
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	SU11274	99.0035
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	2.1901
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	AZD6094	20.5453
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Crizotinib	32.846
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Savolitinib	10.205
SIDM00609	KIRC\|kidney	p.N375S (No)	GDSC	Foretinib	2.1269
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	PHA-665752	6.6267
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Crizotinib	3.3378
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Cabozantinib	11.4291
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	JNJ38877605	39.4066
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	SU11274	11.1359
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Foretinib	0.8607
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	AZD6094	17.0627
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Crizotinib	8.1159
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Savolitinib	6.3461
SIDM00422	UNCLASSIFIED\|Hodgkin_lymphoma	p.R811H (No)	GDSC	Foretinib	2.3568
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Cabozantinib	34.719
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	JNJ38877605	98.2251
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	SU11274	24.7074
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Foretinib	4.5289
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	AZD6094	29.3711
SIDM00534	COREAD\|large_intestine	p.L455I (No)	GDSC	Crizotinib	3.2086
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	PHA-665752	76.7299
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Crizotinib	80.6222
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Cabozantinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	JNJ38877605	33.1884
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	SU11274	66.4945
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Foretinib	215.4655
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	AZD6094	86.9171
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Crizotinib	274.07
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Savolitinib	90.995
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.E302K (No)	GDSC	Foretinib	6.4082
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Cabozantinib	3.8426
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	JNJ38877605	89.3803
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	SU11274	11.553
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Foretinib	0.2985
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	AZD6094	20.6311
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Crizotinib	253.4
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Savolitinib	23.784
SIDM00371	PAAD\|pancreas	p.T200A (No)	GDSC	Foretinib	32.492
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	PHA-665752	27.0323
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Crizotinib	18.617
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Cabozantinib	46.7686
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	JNJ38877605	94.1225
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	SU11274	32.2586
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Foretinib	1.7979
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	AZD6094	11.3871
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Crizotinib	11.832
SIDM00741	SCLC\|lung_small_cell_carcinoma	p.S323G (No)	GDSC	Savolitinib	1.9267
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	PHA-665752	21.0462
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Crizotinib	10.0853
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Cabozantinib	16.1575
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	JNJ38877605	47.0516
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	SU11274	28.598
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Foretinib	0.5605
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	AZD6094	24.7541
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Crizotinib	21.337
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Savolitinib	8.8349
SIDM00245	SCLC\|lung_small_cell_carcinoma	p.R1040Q (No)	GDSC	Foretinib	3.1113
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	3.2546
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	31.9893
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	SU11274	19.4659
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	Foretinib	0.2996
SIDM01082	HNSC\|head_and_neck	p.N375S (No)	GDSC	AZD6094	17.8393
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	Cabozantinib	14.0564
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	JNJ38877605	142.7773
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	SU11274	72.7507
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	Foretinib	1.7942
SIDM01220	GBM\|glioma	p.R988C (No)	GDSC	AZD6094	27.9689
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	PHA-665752	9.7647
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Crizotinib	7.9656
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Cabozantinib	3.557
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	JNJ38877605	102.8285
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	SU11274	16.593
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Foretinib	0.3514
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	AZD6094	10.393
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Crizotinib	15.905
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Savolitinib	6.8906
SIDM00342	ALL\|lymphoblastic_T_cell_leukaemia	p.W1338L (No)	GDSC	Foretinib	0.3999
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	Cabozantinib	5.6829
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	JNJ38877605	30.0466
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	SU11274	7.176
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	Foretinib	0.4209
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	AZD6094	12.1427
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	Crizotinib	5.6649
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	Savolitinib	4.8904
SIDM01087	SKCM\|melanoma	p.T17I (No)	GDSC	Foretinib	1.8246
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Cabozantinib	107.4008
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	JNJ38877605	382.0028
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	SU11274	210.3991
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Foretinib	5.4278
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	AZD6094	35.6491
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Savolitinib	39.008
SIDM00545	SKCM\|melanoma	p.P366S (No)	GDSC	Foretinib	4.0516
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Cabozantinib	35.5871
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	JNJ38877605	17.5814
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	SU11274	69.9421
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Foretinib	3.5226
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	AZD6094	36.7144
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Savolitinib	24.893
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.E168K (No)	GDSC	Foretinib	3.3927
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Cabozantinib	144.2481
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	JNJ38877605	104.5121
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	SU11274	101.4449
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Foretinib	121.8592
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	AZD6094	33.2727
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Crizotinib	199.25
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Savolitinib	9.0022
SIDM00114	MESO\|mesothelioma	p.E740K (No)	GDSC	Foretinib	29.013
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	Cabozantinib	47.1726
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	JNJ38877605	141.8334
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	SU11274	41.4572
SIDM00055	LUAD\|lung_NSCLC_adenocarcinoma	p.D94G (No)	GDSC	Foretinib	1.4924
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	PHA-665752	36.0397
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Crizotinib	9.3788
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Cabozantinib	71.6314
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	JNJ38877605	29.858
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	SU11274	10.1539
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Foretinib	5.6349
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	AZD6094	16.4806
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Crizotinib	32.043
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Savolitinib	9.7556
SIDM01064	UNCLASSIFIED\|Hodgkin_lymphoma	p.R988C (No)	GDSC	Foretinib	3.3809
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	PHA-665752	2.2141
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Crizotinib	15.5121
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Cabozantinib	9.417
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	JNJ38877605	71.4406
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	SU11274	11.1552
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Foretinib	1.3415
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	AZD6094	9.5249
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Crizotinib	11.279
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Savolitinib	20.136
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R191W (No)	GDSC	Foretinib	2.078
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	Cabozantinib	3.7646
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	JNJ38877605	20.6787
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	SU11274	21.5341
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	Foretinib	0.3739
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	AZD6094	18.5803
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	Crizotinib	11.734
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	Savolitinib	17.071
SIDM00855	UNCLASSIFIED\|soft_tissue_other	p.T1010I (Yes)	GDSC	Foretinib	0.3083
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	PHA-665752	30.2212
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	Crizotinib	15.9336
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	Cabozantinib	37.2902
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	JNJ38877605	235.0803
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	SU11274	120.327
SIDM00254	NB\|neuroblastoma	p.G24E (No)	GDSC	AZD6094	19.9005
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (No)	GDSC	PHA-665752	1.8825
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (No)	GDSC	Crizotinib	10.1604
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (No)	GDSC	Cabozantinib	38.2563
SIDM01173	UNCLASSIFIED\|rhabdomyosarcoma	p.G24E (No)	GDSC	Foretinib	1.7401
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Cabozantinib	52.2087
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	JNJ38877605	188.7186
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	SU11274	105.5962
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Foretinib	2.3867
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	AZD6094	36.7036
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Crizotinib	18.457
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Savolitinib	18.399
SIDM01072	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.L1158F (No)	GDSC	Foretinib	1.3149
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	PHA-665752	36.2133
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Crizotinib	49.2184
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Cabozantinib	137.8718
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	JNJ38877605	83.3034
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	SU11274	232.19
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Foretinib	8.3899
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	AZD6094	24.7663
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Crizotinib	11.231
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Savolitinib	66.08
SIDM00645	LUAD\|lung_NSCLC_adenocarcinoma	p.N375S (No)	GDSC	Foretinib	23.473
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Cabozantinib	15.8876
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	JNJ38877605	63.2654
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	SU11274	260.2295
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Foretinib	0.596
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	AZD6094	38.4646
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Crizotinib	53.34
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Savolitinib	53.911
SIDM00465	OV\|ovary	p.N375K (No)	GDSC	Foretinib	7.8612
SIDM00417	MM\|myeloma	p.T1010I (Yes)	GDSC	AZD6094	30.4855
SIDM00417	MM\|myeloma	p.T1010I (Yes)	GDSC	Crizotinib	37.401
SIDM00417	MM\|myeloma	p.T1010I (Yes)	GDSC	Savolitinib	18.397
SIDM00417	MM\|myeloma	p.T1010I (Yes)	GDSC	Foretinib	9.6513
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	PHA-665752	17.3727
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Crizotinib	8.3654
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Cabozantinib	15.4167
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	JNJ38877605	172.8538
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	SU11274	85.9048
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Foretinib	1.2978
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	AZD6094	11.1653
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Crizotinib	14.301
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Savolitinib	4.9434
SIDM01018	UNCLASSIFIED\|Hodgkin_lymphoma	p.N375S (No)	GDSC	Foretinib	5.7157
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Cabozantinib	3.1951
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	JNJ38877605	39.3897
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	SU11274	24.658
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Foretinib	0.3922
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	AZD6094	9.2751
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Savolitinib	18.861
SIDM01138	PAAD\|pancreas	p.N375S (No)	GDSC	Foretinib	11.253
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	PHA-665752	3.1427
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Crizotinib	2.3909
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Cabozantinib	5.6926
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	JNJ38877605	18.2483
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	SU11274	29.9131
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Foretinib	1.0657
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	AZD6094	1.9661
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Crizotinib	15.7
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Savolitinib	5.4012
SIDM00490	GBM\|glioma	p.L604V (No)	GDSC	Foretinib	1.6438
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	PHA-665752	34.0749
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Crizotinib	7.4123
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Cabozantinib	19.1626
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	JNJ38877605	326.1554
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	SU11274	18.2882
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Foretinib	0.5741
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	AZD6094	13.7037
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Crizotinib	23.738
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Savolitinib	14.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.A1381V (No)	GDSC	Foretinib	1.8666
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Cabozantinib	8.3183
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	JNJ38877605	37.7622
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	SU11274	18.9212
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Foretinib	1.1726
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	AZD6094	22.4841
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Crizotinib	2.7879
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Savolitinib	6.5443
SIDM00537	COREAD\|large_intestine	p.T950A (No)	GDSC	Foretinib	1.3073
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	PHA-665752	8.6507
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	0.883
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Cabozantinib	6.721
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	JNJ38877605	92.0916
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	SU11274	49.3636
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	0.6384
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Crizotinib	0.2722
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Savolitinib	5.9323
SIDM00384	DLBC\|B_cell_lymphoma	p.N375S (No)	GDSC	Foretinib	1.0903
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	PHA-665752	41.4596
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Crizotinib	20.9555
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Cabozantinib	41.8362
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	JNJ38877605	433.5842
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	SU11274	85.5915
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Foretinib	1.9663
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	AZD6094	44.4746
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Crizotinib	50.258
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Savolitinib	27.384
SIDM00653	SCLC\|lung_small_cell_carcinoma	p.T1010I (Yes)	GDSC	Foretinib	9.8277
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	Cabozantinib	18.5354
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	JNJ38877605	263.8416
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	SU11274	136.6857
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	Foretinib	1.1805
SIDM01150	LUAD\|lung_NSCLC_adenocarcinoma	p.I638L (No)	GDSC	AZD6094	39.9478
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	PHA-665752	20.6426
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Crizotinib	13.6056
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Cabozantinib	15.7624
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	JNJ38877605	36.8225
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	SU11274	8.6945
SIDM00927	SCLC\|lung_small_cell_carcinoma	p.A204fs*3 (No)	GDSC	Foretinib	0.8967
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Cabozantinib	12.8638
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	JNJ38877605	47.3554
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	SU11274	11.8309
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Foretinib	1.8128
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	AZD6094	17.3754
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Crizotinib	7.2885
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Savolitinib	5.1376
SIDM00875	UNCLASSIFIED\|breast	p.S572N (No)	GDSC	Foretinib	3.0854
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	Cabozantinib	16.8038
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	JNJ38877605	17.7826
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	SU11274	14.4601
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	Foretinib	0.9296
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	AZD6094	28.2543
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	Crizotinib	34.545
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	Savolitinib	39.255
SIDM00123	KIRC\|kidney	p.T1010I (Yes)	GDSC	Foretinib	1.4616
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	PHA-665752	19.7585
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	25.7678
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Cabozantinib	74.4918
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	JNJ38877605	286.6712
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	SU11274	111.7196
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Foretinib	3.7287
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	AZD6094	32.3451
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Crizotinib	42.715
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Savolitinib	9.2801
SIDM00796	UNCLASSIFIED\|head_and_neck	p.N375S (No)	GDSC	Foretinib	6.5524
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	JNJ38877605	474.3958
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	SU11274	262.6236
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Foretinib	7.8838
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	AZD6094	55.1173
SIDM00193	COREAD\|large_intestine	p.A320V (No)	GDSC	Crizotinib	42.439
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Cabozantinib	133.9123
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	JNJ38877605	474.3958
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	SU11274	262.6236
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Foretinib	7.8838
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	AZD6094	55.1173
SIDM00193	COREAD\|large_intestine	p.R591W (No)	GDSC	Crizotinib	42.439
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	JNJ38877605	67.4695
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	SU11274	75.3894
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Foretinib	3.6532
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	AZD6094	26.6431
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Crizotinib	4.5563
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Savolitinib	4.7435
SIDM00118	COREAD\|large_intestine	p.K303T (No)	GDSC	Foretinib	4.088
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Cabozantinib	28.7329
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	JNJ38877605	67.4695
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	SU11274	75.3894
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	3.6532
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	AZD6094	26.6431
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Crizotinib	4.5563
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Savolitinib	4.7435
SIDM00118	COREAD\|large_intestine	p.N375S (No)	GDSC	Foretinib	4.088

All proteins holding degron of DYR

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00139	Kinesin-like protein KIF2A	CBL_MET	209:211	DYR	CBL	0.9462	More...
O00571	ATP-dependent RNA helicase DDX3X	CBL_MET	601:603	DYR	CBL	0.9982	More...
O00629	Importin subunit alpha-3	CBL_MET	65:67	DYR	CBL	0.7682	More...
O14646	Chromodomain-helicase-DNA-binding protein 1	CBL_MET	1657:1659	DYR	CBL	0.9833	More...
O15020	Spectrin beta chain, non-erythrocytic 2	CBL_MET	2288:2290	DYR	CBL	0.6427	More...
O15047	Histone-lysine N-methyltransferase SETD1A	CBL_MET	424:426	DYR	CBL	0.8226	More...
O15523	ATP-dependent RNA helicase DDX3Y	CBL_MET	599:601	DYR	CBL	0.9998	More...
O15553	Pyrin	CBL_MET	723:725	DYR	CBL	0.8162	More...
O43676	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	CBL_MET	18:20	DYR	CBL	0.9451	More...
O60264	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	CBL_MET	140:142	DYR	CBL	0.9955	More...
O60264	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5	CBL_MET	718:720	DYR	CBL	0.8031	More...
O75334	Liprin-alpha-2	CBL_MET	568:570	DYR	CBL	0.5843	More...
O75376	Nuclear receptor corepressor 1	CBL_MET	42:44	DYR	CBL	0.7623	More...
O75420	GRB10-interacting GYF protein 1	CBL_MET	38:40	DYR	CBL	0.6199	More...
O75879	Glutamyl-tRNA	CBL_MET	334:336	DYR	CBL	0.9961	More...
O75925	E3 SUMO-protein ligase PIAS1	CBL_MET	526:528	DYR	CBL	0.814	More...
O95271	Poly [ADP-ribose] polymerase tankyrase-1	CBL_MET	651:653	DYR	CBL	0.5061	More...
O95359	Transforming acidic coiled-coil-containing protein 2	CBL_MET	2518:2520	DYR	CBL	0.9518	More...
O95948	One cut domain family member 2	CBL_MET	118:120	DYR	CBL	0.8889	More...
P00736	Complement C1r subcomponent	CBL_MET	545:547	DYR	CBL	0.6636	More...
P04264	Keratin, type II cytoskeletal 1	CBL_MET	265:267	DYR	CBL	0.8471	More...
P08581	Hepatocyte growth factor receptor	CBL_MET	1002:1004	DYR	CBL	0.9838	More...
P0C1Z6	TCF3 fusion partner	CBL_MET	130:132	DYR	CBL	0.6994	More...
P10515	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	CBL_MET	305:307	DYR	CBL	0.8796	More...
P13942	Collagen alpha-2	CBL_MET	353:355	DYR	CBL	0.5731	More...
P20810	Calpastatin	CBL_MET	480:482	DYR	CBL	0.9683	More...
P23588	Eukaryotic translation initiation factor 4B	CBL_MET	290:292	DYR	CBL	0.9781	More...
P24666	Low molecular weight phosphotyrosine protein phosphatase	CBL_MET	57:59	DYR	CBL	0.5377	More...
P25440	Bromodomain-containing protein 2	CBL_MET	407:409	DYR	CBL	0.9586	More...
P26842	CD27 antigen	CBL_MET	250:252	DYR	CBL	0.6901	More...
P28370	Probable global transcription activator SNF2L1	CBL_MET	143:145	DYR	CBL	0.74	More...
P30305	M-phase inducer phosphatase 2	CBL_MET	541:543	DYR	CBL	0.9803	More...
P35968	Vascular endothelial growth factor receptor 2	CBL_MET	120:122	DYR	CBL	0.5317	More...
P40145	Adenylate cyclase type 8	CBL_MET	1148:1150	DYR	CBL	0.7268	More...
P40424	Pre-B-cell leukemia transcription factor 1	CBL_MET	149:151	DYR	CBL	0.8542	More...
P40425	Pre-B-cell leukemia transcription factor 2	CBL_MET	160:162	DYR	CBL	0.8868	More...
P41587	Vasoactive intestinal polypeptide receptor 2	CBL_MET	402:404	DYR	CBL	0.6233	More...
P49736	DNA replication licensing factor MCM2	CBL_MET	80:82	DYR	CBL	0.9704	More...
P49760	Dual specificity protein kinase CLK2	CBL_MET	94:96	DYR	CBL	0.9942	More...
P51805	Plexin-A3	CBL_MET	1298:1300	DYR	CBL	0.9239	More...
P51825	AF4/FMR2 family member 1	CBL_MET	316:318	DYR	CBL	0.9069	More...
P51854	Transketolase-like protein 1	CBL_MET	282:284	DYR	CBL	0.9474	More...
P52756	RNA-binding protein 5	CBL_MET	53:55	DYR	CBL	0.9985	More...
P52756	RNA-binding protein 5	CBL_MET	86:88	DYR	CBL	0.9953	More...
P54760	Ephrin type-B receptor 4	CBL_MET	836:838	DYR	CBL	0.633	More...
P54762	Ephrin type-B receptor 1	CBL_MET	840:842	DYR	CBL	0.7094	More...
P56715	Oxygen-regulated protein 1	CBL_MET	1593:1595	DYR	CBL	0.9936	More...
P62333	26S proteasome regulatory subunit 10B	CBL_MET	11:13	DYR	CBL	0.5589	More...
P78332	RNA-binding protein 6	CBL_MET	84:86	DYR	CBL	0.8516	More...
P78332	RNA-binding protein 6	CBL_MET	134:136	DYR	CBL	0.9878	More...
P78332	RNA-binding protein 6	CBL_MET	144:146	DYR	CBL	0.9933	More...
P78332	RNA-binding protein 6	CBL_MET	400:402	DYR	CBL	0.994	More...
P78332	RNA-binding protein 6	CBL_MET	444:446	DYR	CBL	0.9571	More...
P78559	Microtubule-associated protein 1A	CBL_MET	1908:1910	DYR	CBL	0.7957	More...
P84103	Serine/arginine-rich splicing factor 3	CBL_MET	103:105	DYR	CBL	0.9202	More...
P98175	RNA-binding protein 10	CBL_MET	35:37	DYR	CBL	0.8937	More...
P98175	RNA-binding protein 10	CBL_MET	40:42	DYR	CBL	0.9885	More...
P98175	RNA-binding protein 10	CBL_MET	101:103	DYR	CBL	0.9929	More...
P98175	RNA-binding protein 10	CBL_MET	106:108	DYR	CBL	0.9935	More...
Q01668	Voltage-dependent L-type calcium channel subunit alpha-1D	CBL_MET	807:809	DYR	CBL	0.9538	More...
Q01804	OTU domain-containing protein 4	CBL_MET	360:362	DYR	CBL	0.9712	More...
Q01973	Inactive tyrosine-protein kinase transmembrane receptor ROR1	CBL_MET	320:322	DYR	CBL	0.9644	More...
Q04912	Macrophage-stimulating protein receptor	CBL_MET	292:294	DYR	CBL	0.9076	More...
Q04912	Macrophage-stimulating protein receptor	CBL_MET	1016:1018	DYR	CBL	0.9418	More...
Q07954	Prolow-density lipoprotein receptor-related protein 1	CBL_MET	2242:2244	DYR	CBL	0.5092	More...
Q08211	ATP-dependent RNA helicase A	CBL_MET	1233:1235	DYR	CBL	0.9757	More...
Q08378	Golgin subfamily A member 3	CBL_MET	248:250	DYR	CBL	0.9928	More...
Q08380	Galectin-3-binding protein	CBL_MET	452:454	DYR	CBL	0.7593	More...
Q12802	A-kinase anchor protein 13	CBL_MET	823:825	DYR	CBL	0.8159	More...
Q13595	Transformer-2 protein homolog alpha	CBL_MET	253:255	DYR	CBL	0.53	More...
Q13796	Protein Shroom2	CBL_MET	1018:1020	DYR	CBL	0.987	More...
Q14004	Cyclin-dependent kinase 13	CBL_MET	1276:1278	DYR	CBL	0.9353	More...
Q14247	Src substrate cortactin	CBL_MET	452:454	DYR	CBL	0.9377	More...
Q14257	Reticulocalbin-2	CBL_MET	214:216	DYR	CBL	0.5984	More...
Q14722	Voltage-gated potassium channel subunit beta-1	CBL_MET	416:418	DYR	CBL	0.9463	More...
Q14966	Zinc finger protein 638	CBL_MET	1482:1484	DYR	CBL	0.9903	More...
Q15003	Condensin complex subunit 2	CBL_MET	269:271	DYR	CBL	0.6611	More...
Q15464	SH2 domain-containing adapter protein B	CBL_MET	26:28	DYR	CBL	0.5914	More...
Q15746	Myosin light chain kinase, smooth muscle	CBL_MET	1448:1450	DYR	CBL	0.6844	More...
Q16625	Occludin	CBL_MET	466:468	DYR	CBL	0.9972	More...
Q2LD37	Transmembrane protein KIAA1109	CBL_MET	3517:3519	DYR	CBL	0.7981	More...
Q2TAL6	Brorin	CBL_MET	149:151	DYR	CBL	0.987	More...
Q5T011	KICSTOR complex protein SZT2	CBL_MET	759:761	DYR	CBL	0.8358	More...
Q5T200	Zinc finger CCCH domain-containing protein 13	CBL_MET	506:508	DYR	CBL	0.9991	More...
Q5T5U3	Rho GTPase-activating protein 21	CBL_MET	888:890	DYR	CBL	0.9971	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	CBL_MET	832:834	DYR	CBL	0.992	More...
Q5VUA4	Zinc finger protein 318	CBL_MET	223:225	DYR	CBL	0.5829	More...
Q5VUB5	Protein FAM171A1	CBL_MET	484:486	DYR	CBL	0.9956	More...
Q5VV43	Dyslexia-associated protein KIAA0319	CBL_MET	159:161	DYR	CBL	0.8877	More...
Q6IQ20	N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	CBL_MET	47:49	DYR	CBL	0.988	More...
Q6IS24	Polypeptide N-acetylgalactosaminyltransferase 17	CBL_MET	136:138	DYR	CBL	0.6035	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	CBL_MET	864:866	DYR	CBL	0.5334	More...
Q6UB99	Ankyrin repeat domain-containing protein 11	CBL_MET	899:901	DYR	CBL	0.7809	More...
Q6ZS17	Rho family-interacting cell polarization regulator 1	CBL_MET	807:809	DYR	CBL	0.861	More...
Q7Z2W4	Zinc finger CCCH-type antiviral protein 1	CBL_MET	409:411	DYR	CBL	0.5401	More...
Q7Z4T9	Cilia- and flagella-associated protein 91	CBL_MET	194:196	DYR	CBL	0.6194	More...
Q7Z698	Sprouty-related, EVH1 domain-containing protein 2	CBL_MET	230:232	DYR	CBL	0.9995	More...
Q7Z699	Sprouty-related, EVH1 domain-containing protein 1	CBL_MET	260:262	DYR	CBL	0.8061	More...
Q86UL8	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2	CBL_MET	1113:1115	DYR	CBL	0.5682	More...
Q86UW6	NEDD4-binding protein 2	CBL_MET	1621:1623	DYR	CBL	0.9143	More...
Q86WI1	Fibrocystin-L	CBL_MET	3717:3719	DYR	CBL	0.5999	More...
Q86YV5	Inactive tyrosine-protein kinase PRAG1	CBL_MET	1281:1283	DYR	CBL	0.8047	More...
Q8IV36	Protein HID1	CBL_MET	275:277	DYR	CBL	0.7188	More...
Q8IXQ5	Kelch-like protein 7	CBL_MET	292:294	DYR	CBL	0.6031	More...
Q8IYB7	DIS3-like exonuclease 2	CBL_MET	5:7	DYR	CBL	0.7018	More...
Q8NDX1	PH and SEC7 domain-containing protein 4	CBL_MET	4:6	DYR	CBL	0.9301	More...
Q8NEY8	Periphilin-1	CBL_MET	57:59	DYR	CBL	0.9982	More...
Q8NFW5	Diencephalon/mesencephalon homeobox protein 1	CBL_MET	36:38	DYR	CBL	0.9784	More...
Q8TCS8	Polyribonucleotide nucleotidyltransferase 1, mitochondrial	CBL_MET	101:103	DYR	CBL	0.6954	More...
Q8TDC0	Myozenin-3	CBL_MET	190:192	DYR	CBL	0.7683	More...
Q8TDJ6	DmX-like protein 2	CBL_MET	2716:2718	DYR	CBL	0.8574	More...
Q8TEB1	DDB1- and CUL4-associated factor 11	CBL_MET	406:408	DYR	CBL	0.9704	More...
Q8TF46	DIS3-like exonuclease 1	CBL_MET	371:373	DYR	CBL	0.9736	More...
Q8WVM8	Sec1 family domain-containing protein 1	CBL_MET	565:567	DYR	CBL	0.9885	More...
Q92620	Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16	CBL_MET	498:500	DYR	CBL	0.9106	More...
Q92804	TATA-binding protein-associated factor 2N	CBL_MET	582:584	DYR	CBL	0.8251	More...
Q92835	Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	CBL_MET	1160:1162	DYR	CBL	0.9908	More...
Q92896	Golgi apparatus protein 1	CBL_MET	230:232	DYR	CBL	0.9413	More...
Q92896	Golgi apparatus protein 1	CBL_MET	931:933	DYR	CBL	0.8383	More...
Q96AH0	SOSS complex subunit B2	CBL_MET	118:120	DYR	CBL	0.6249	More...
Q96G01	Protein bicaudal D homolog 1	CBL_MET	299:301	DYR	CBL	0.9969	More...
Q96J84	Kin of IRRE-like protein 1	CBL_MET	624:626	DYR	CBL	0.925	More...
Q96JC1	Vam6/Vps39-like protein	CBL_MET	390:392	DYR	CBL	0.5993	More...
Q96JE7	Protein transport protein Sec16B	CBL_MET	150:152	DYR	CBL	0.7792	More...
Q96JE9	Microtubule-associated protein 6	CBL_MET	124:126	DYR	CBL	0.9892	More...
Q96K21	Abscission/NoCut checkpoint regulator	CBL_MET	348:350	DYR	CBL	0.5257	More...
Q96NW4	Ankyrin repeat domain-containing protein 27	CBL_MET	666:668	DYR	CBL	0.9069	More...
Q96PK6	RNA-binding protein 14	CBL_MET	613:615	DYR	CBL	0.9916	More...
Q96PK6	RNA-binding protein 14	CBL_MET	634:636	DYR	CBL	0.9946	More...
Q96S66	Chloride channel CLIC-like protein 1	CBL_MET	386:388	DYR	CBL	0.9205	More...
Q96T37	RNA-binding protein 15	CBL_MET	304:306	DYR	CBL	0.9655	More...
Q99595	Mitochondrial import inner membrane translocase subunit Tim17-A	CBL_MET	166:168	DYR	CBL	0.9893	More...
Q99795	Cell surface A33 antigen	CBL_MET	300:302	DYR	CBL	0.8146	More...
Q99932	Sperm-associated antigen 8	CBL_MET	385:387	DYR	CBL	0.5131	More...
Q9BQS8	FYVE and coiled-coil domain-containing protein 1	CBL_MET	1271:1273	DYR	CBL	0.5789	More...
Q9BSE2	Transmembrane protein 79	CBL_MET	387:389	DYR	CBL	0.6448	More...
Q9BTA9	WW domain-containing adapter protein with coiled-coil	CBL_MET	186:188	DYR	CBL	0.7509	More...
Q9BTA9	WW domain-containing adapter protein with coiled-coil	CBL_MET	231:233	DYR	CBL	0.7463	More...
Q9BZC7	ATP-binding cassette sub-family A member 2	CBL_MET	1395:1397	DYR	CBL	0.9909	More...
Q9BZJ0	Crooked neck-like protein 1	CBL_MET	272:274	DYR	CBL	0.6918	More...
Q9H078	Caseinolytic peptidase B protein homolog	CBL_MET	278:280	DYR	CBL	0.5353	More...
Q9H0G5	Nuclear speckle splicing regulatory protein 1	CBL_MET	336:338	DYR	CBL	0.6151	More...
Q9H116	GDNF-inducible zinc finger protein 1	CBL_MET	257:259	DYR	CBL	0.6224	More...
Q9H270	Vacuolar protein sorting-associated protein 11 homolog	CBL_MET	570:572	DYR	CBL	0.99	More...
Q9H7E9	UPF0488 protein C8orf33	CBL_MET	165:167	DYR	CBL	0.8994	More...
Q9HAD4	WD repeat-containing protein 41	CBL_MET	54:56	DYR	CBL	0.8451	More...
Q9HAU0	Pleckstrin homology domain-containing family A member 5	CBL_MET	803:805	DYR	CBL	0.9956	More...
Q9HAZ1	Dual specificity protein kinase CLK4	CBL_MET	66:68	DYR	CBL	0.8055	More...
Q9HCM1	Retroelement silencing factor 1	CBL_MET	210:212	DYR	CBL	0.9737	More...
Q9HCQ5	Polypeptide N-acetylgalactosaminyltransferase 9	CBL_MET	135:137	DYR	CBL	0.9537	More...
Q9HD67	Unconventional myosin-X	CBL_MET	1120:1122	DYR	CBL	0.6143	More...
Q9NQV6	PR domain zinc finger protein 10	CBL_MET	913:915	DYR	CBL	0.9044	More...
Q9NRA8	Eukaryotic translation initiation factor 4E transporter	CBL_MET	782:784	DYR	CBL	0.8248	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	CBL_MET	563:565	DYR	CBL	0.9622	More...
Q9NVM9	Integrator complex subunit 13	CBL_MET	412:414	DYR	CBL	0.9056	More...
Q9NWK9	Box C/D snoRNA protein 1	CBL_MET	277:279	DYR	CBL	0.8233	More...
Q9NYF0	Dapper homolog 1	CBL_MET	675:677	DYR	CBL	0.996	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	56:58	DYR	CBL	0.7315	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	60:62	DYR	CBL	0.9219	More...
Q9NYF8	Bcl-2-associated transcription factor 1	CBL_MET	407:409	DYR	CBL	0.8675	More...
Q9NZP8	Complement C1r subcomponent-like protein	CBL_MET	327:329	DYR	CBL	0.7258	More...
Q9P0K7	Ankycorbin	CBL_MET	661:663	DYR	CBL	0.6245	More...
Q9P1A6	Disks large-associated protein 2	CBL_MET	831:833	DYR	CBL	0.927	More...
Q9P2B4	CTTNBP2 N-terminal-like protein	CBL_MET	532:534	DYR	CBL	0.9696	More...
Q9P2N4	A disintegrin and metalloproteinase with thrombospondin motifs 9	CBL_MET	1313:1315	DYR	CBL	0.9337	More...
Q9UER7	Death domain-associated protein 6	CBL_MET	343:345	DYR	CBL	0.6964	More...
Q9UEW8	STE20/SPS1-related proline-alanine-rich protein kinase	CBL_MET	443:445	DYR	CBL	0.6777	More...
Q9UIW2	Plexin-A1	CBL_MET	441:443	DYR	CBL	0.9623	More...
Q9UIW2	Plexin-A1	CBL_MET	1323:1325	DYR	CBL	0.8813	More...
Q9UJM3	ERBB receptor feedback inhibitor 1	CBL_MET	297:299	DYR	CBL	0.9805	More...
Q9ULE0	Protein WWC3	CBL_MET	1035:1037	DYR	CBL	0.5665	More...
Q9UPN3	Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5	CBL_MET	878:880	DYR	CBL	0.7589	More...
Q9UPR5	Sodium/calcium exchanger 2	CBL_MET	430:432	DYR	CBL	0.624	More...
Q9UQ26	Regulating synaptic membrane exocytosis protein 2	CBL_MET	986:988	DYR	CBL	0.5284	More...
Q9UQQ2	SH2B adapter protein 3	CBL_MET	88:90	DYR	CBL	0.9861	More...
Q9Y2I7	1-phosphatidylinositol 3-phosphate 5-kinase	CBL_MET	1154:1156	DYR	CBL	0.9899	More...
Q9Y4F3	Meiosis regulator and mRNA stability factor 1	CBL_MET	799:801	DYR	CBL	0.8743	More...
Q9Y4X5	E3 ubiquitin-protein ligase ARIH1	CBL_MET	98:100	DYR	CBL	0.6904	More...
Q9Y6N7	Roundabout homolog 1	CBL_MET	1125:1127	DYR	CBL	0.919	More...
Q9Y6W3	Calpain-7	CBL_MET	764:766	DYR	CBL	0.8602	More...
O60330	Protocadherin gamma-A12	CBL_MET	890:892	DYR	CBL	0.5991	More...
P42696	RNA-binding protein 34	CBL_MET	32:34	DYR	CBL	0.8024	More...
Q2MJR0	Sprouty-related, EVH1 domain-containing protein 3	CBL_MET	222:224	DYR	CBL	0.9902	More...
Q2T9L4	Inhibitory synaptic factor 1	CBL_MET	138:140	DYR	CBL	0.7706	More...
Q53G44	Interferon-induced protein 44-like	CBL_MET	187:189	DYR	CBL	0.5931	More...
Q5SRI9	Glycoprotein endo-alpha-1,2-mannosidase	CBL_MET	426:428	DYR	CBL	0.9969	More...
Q66K14	TBC1 domain family member 9B	CBL_MET	997:999	DYR	CBL	0.9546	More...
Q6V1P9	Protocadherin-23	CBL_MET	1364:1366	DYR	CBL	0.9843	More...
Q96A35	39S ribosomal protein L24, mitochondrial	CBL_MET	103:105	DYR	CBL	0.8186	More...
Q9BRU2	Transcription elongation factor A protein-like 7	CBL_MET	53:55	DYR	CBL	0.8569	More...
Q9C0D7	Probable ribonuclease ZC3H12C	CBL_MET	616:618	DYR	CBL	0.8826	More...
Q9HCL0	Protocadherin-18	CBL_MET	942:944	DYR	CBL	0.8495	More...
Q9NW75	G patch domain-containing protein 2	CBL_MET	102:104	DYR	CBL	0.9895	More...
Q9UN70	Protocadherin gamma-C3	CBL_MET	892:894	DYR	CBL	0.7341	More...
Q9Y2H8	Zinc finger protein 510	CBL_MET	119:121	DYR	CBL	0.7189	More...
Q9Y5F7	Protocadherin gamma-C4	CBL_MET	207:209	DYR	CBL	0.7942	More...
Q9Y5F7	Protocadherin gamma-C4	CBL_MET	896:898	DYR	CBL	0.9198	More...
Q9Y5F8	Protocadherin gamma-B7	CBL_MET	887:889	DYR	CBL	0.6353	More...
Q9Y5F9	Protocadherin gamma-B6	CBL_MET	888:890	DYR	CBL	0.6971	More...
Q9Y5G0	Protocadherin gamma-B5	CBL_MET	881:883	DYR	CBL	0.7195	More...
Q9Y5G1	Protocadherin gamma-B3	CBL_MET	887:889	DYR	CBL	0.9024	More...
Q9Y5G2	Protocadherin gamma-B2	CBL_MET	889:891	DYR	CBL	0.8238	More...
Q9Y5G3	Protocadherin gamma-B1	CBL_MET	885:887	DYR	CBL	0.8647	More...
Q9Y5G4	Protocadherin gamma-A9	CBL_MET	890:892	DYR	CBL	0.8201	More...
Q9Y5G5	Protocadherin gamma-A8	CBL_MET	890:892	DYR	CBL	0.8995	More...
Q9Y5G9	Protocadherin gamma-A4	CBL_MET	920:922	DYR	CBL	0.9131	More...
Q9Y5H0	Protocadherin gamma-A3	CBL_MET	890:892	DYR	CBL	0.7424	More...
Q9Y5H1	Protocadherin gamma-A2	CBL_MET	890:892	DYR	CBL	0.8649	More...
Q9Y5H2	Protocadherin gamma-A11	CBL_MET	893:895	DYR	CBL	0.9276	More...
Q9Y5H4	Protocadherin gamma-A1	CBL_MET	889:891	DYR	CBL	0.69	More...
A2AJT9	BCLAF1 and THRAP3 family member 3	CBL_MET	280:282	DYR	CBL	0.8797	More...
A6NCL1	Geminin coiled-coil domain-containing protein 1	CBL_MET	244:246	DYR	CBL	0.9961	More...
O75526	RNA-binding motif protein, X-linked-like-2	CBL_MET	224:226	DYR	CBL	0.9863	More...
Q2TAA8	Translin-associated factor X-interacting protein 1	CBL_MET	27:29	DYR	CBL	0.7834	More...
Q5THK1	Protein PRR14L	CBL_MET	604:606	DYR	CBL	0.9146	More...
Q5VZ52	MORN repeat-containing protein 5	CBL_MET	137:139	DYR	CBL	0.9741	More...
Q8N944	APC membrane recruitment protein 3	CBL_MET	128:130	DYR	CBL	0.9544	More...
Q8WX39	Epididymal-specific lipocalin-9	CBL_MET	115:117	DYR	CBL	0.862	More...
Q96M34	Testis-specific expressed protein 55	CBL_MET	387:389	DYR	CBL	0.8215	More...
Q96M89	Coiled-coil domain-containing protein 138	CBL_MET	113:115	DYR	CBL	0.9465	More...
Q96RT6	cTAGE family member 2	CBL_MET	571:573	DYR	CBL	0.8733	More...
Q9BRR8	G patch domain-containing protein 1	CBL_MET	370:372	DYR	CBL	0.9884	More...
Q9H6Y2	WD repeat-containing protein 55	CBL_MET	334:336	DYR	CBL	0.7633	More...
Q9Y5G7	Protocadherin gamma-A6	CBL_MET	890:892	DYR	CBL	0.8811	More...
A1A4G5	Leukemia NUP98 fusion partner 1	CBL_MET	84:86	DYR	CBL	0.8519	More...
A6NKL6	Transmembrane protein 200C	CBL_MET	477:479	DYR	CBL	0.9502	More...
P0C7V6	Putative transcription factor SPT20 homolog-like 2	CBL_MET	148:150	DYR	CBL	0.5386	More...
Q3ZLR7	Transcription factor SPT20 homolog-like 1	CBL_MET	148:150	DYR	CBL	0.5131	More...
Q8N7X1	RNA-binding motif protein, X-linked-like-3	CBL_MET	271:273	DYR	CBL	0.9985	More...
F2Z3F1	Uncharacterized protein C5orf67	CBL_MET	42:44	DYR	CBL	0.5833	More...
Q8IXP5	Uncharacterized protein C11orf53	CBL_MET	67:69	DYR	CBL	0.9873	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DYR

Degron related mutations and impact score

Drug responses associated with MET mutations

All proteins holding degron of DYR