DegronMD - P23588(EIF4B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E481Q	TCGA-17-Z023	LUAD	TCGA	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation altering degron motif	0.6744
p.W484L	TCGA-53-7626	LUAD	TCGA	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.3056
p.R287M	TCGA-A3-A6NL	KIRC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.25
p.G284E	TCGA-B5-A3FA	UCEC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1667
p.R286H	TCGA-BS-A0UV	UCEC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.R286H	TCGA-DF-A2KU	UCEC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.R286H	SIDM00216	Colorectal Carcinoma	GDSC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.R286H	ACH-000989	Colon/Colorectal Cancer	CCLE	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.R286H	ACH-001991	Primary	CCLE	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.R286H	SNU-175	large intestine	COSMIC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.D289N	TCGA-C5-A1M9	CESC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.3056
p.R286C	TCGA-CN-5369	HNSC	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2222
p.Y298C	TCGA-D7-5578	STAD	TCGA	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6111
p.R297S	TCGA-FS-A1ZB	SKCM	TCGA	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1944
p.L297I	DO10880	GBM	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1944
p.D280Y	DO228948	LICA	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.0556
p.R300Q	DO228950	LICA	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1111
p.R300Q	DO41871	UCEC	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1111
p.G288C	DO229027	LICA	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2778
p.G288C	DO47407	SKCM	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.2778
p.G469V	DO229031	LICA	ICGC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0556
p.K298N	DO229036	LICA	ICGC	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6111
p.K298N	DO229051	LICA	ICGC	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6111
p.D285N	DO23500	LINC	ICGC	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6389
p.D285N	HCC2218	breast	COSMIC	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6389
p.L297V	DO24712	LUAD	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.1944
p.D285E	DO46792	PRAD	ICGC	DYR	CBL_MET	290:292	Mutation blocking phosphorylation signal	0.6389
p.P290L	DO47480	SKCM	ICGC	DYR	CBL_MET	290:292	Mutation altering degron motif	0.7582
p.P293S	DO38006	SKCM	ICGC	DYR	CBL_MET	290:292	Mutation rewiring degron network	0.3056
p.A476V	DO41752	UCEC	ICGC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.25
p.P472H	SIDM00084	Glioblastoma	GDSC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation substituting flanking lysine	0.25
p.P472H	ACH-000376	Brain Cancer	CCLE	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation substituting flanking lysine	0.25
p.S479C	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation altering degron motif	0.7541
p.Q291E	BT-474	breast	COSMIC	DYR	CBL_MET	290:292	Mutation altering degron motif	0.6744
p.D492G	KMH-2	thyroid	COSMIC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation rewiring degron network	0.0833
p.E488K	BC-1	haematopoietic and lymphoid tissue	COSMIC	PKENA	DEG_APCC_KENBOX_2	479:483	Mutation blocking phosphorylation signal	0.6389

Kaplan plot for EIF4B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EIF4B

UniProt ID: P23588

Entrez ID: 1975

Protein name: Eukaryotic translation initiation factor 4B (eIF-4B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EIF4B in