DegronMD

Uniprot ID: P23588

Source protein: Eukaryotic translation initiation factor 4B

Source gene: EIF4B

Class: DEG_APCC_KENBOX_2

Location: 479:483

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9927

ASA_SCORE: 95.26

COIL: 0.703

CONS_SCORE: 0.3863

DSS_SCORE: 0.7292

HELIX: 0.2752

FCONS_SCORE: 1.2014

RIG_SCORE: 0.6118

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E481Q	TCGA-17-Z023	LUAD	TCGA	PKENA	DEG_APCC_KENBOX_2	0.6744
p.W484L	TCGA-53-7626	LUAD	TCGA	PKENA	DEG_APCC_KENBOX_2	0.3056
p.G469V	DO229031	LICA	ICGC	PKENA	DEG_APCC_KENBOX_2	0.0556
p.A476V	DO41752	UCEC	ICGC	PKENA	DEG_APCC_KENBOX_2	0.25
p.P472H	SIDM00084	Glioblastoma	GDSC	PKENA	DEG_APCC_KENBOX_2	0.25
p.P472H	ACH-000376	Brain Cancer	CCLE	PKENA	DEG_APCC_KENBOX_2	0.25
p.S479C	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PKENA	DEG_APCC_KENBOX_2	0.7541
p.D492G	KMH-2	thyroid	COSMIC	PKENA	DEG_APCC_KENBOX_2	0.0833
p.E488K	BC-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKENA	DEG_APCC_KENBOX_2	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P23588	Eukaryotic translation initiation factor 4B	DEG_APCC_KENBOX_2	479:483	PKENA	APC,CDC20,FZR1	0.9927	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons