DegronMD - Q14257(RCN2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R157Q	TCGA-06-5416	GBM	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.1389
p.D50E	TCGA-5R-AA1C	LIHC	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.D50E	DO219545	LIHC	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.Q163R	TCGA-60-2723	LUSC	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.3056
p.G204E	TCGA-61-1915	OV	TCGA	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.0556
p.P219Q	TCGA-D3-A3CE	SKCM	TCGA	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.25
p.D50N	TCGA-D3-A5GO	SKCM	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.D50N	DO47419	SKCM	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.E173G	TCGA-DD-AAD0	LIHC	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.25
p.L212I	TCGA-EO-A3AY	UCEC	TCGA	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.2778
p.L212I	ACH-000996	Endometrial/Uterine Cancer	CCLE	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.2778
p.D50A	TCGA-NF-A4X2	UCS	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.D218G	TCGA-RD-A8MV	STAD	TCGA	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.2778
p.G220D	DO13845	GBM	ICGC	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.2222
p.R175Q	DO10880	GBM	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.1944
p.G58C	DO228971	LICA	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.0556
p.G222E	DO31100	OV	ICGC	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.1667
p.R165Q	DO33000	PACA	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	DO229216	THCA	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	DO41572	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	SIDM00846	Cervical Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	SIDM00628	Breast Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	MDA-MB-468	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.R165Q	HeLa	cervix	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7329
p.D50G	DO38404	STAD	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.S158F	DO41758	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.1667
p.L168I	DO42528	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.7174
p.K173N	SIDM00630	Breast Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.25
p.K173N	MDA-MB-415	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.25
p.T205M	SIDM00193	Colorectal Carcinoma	GDSC	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.0833
p.T205M	NCI-H630	large intestine	COSMIC	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.0833
p.T205M	SNU-81	large intestine	COSMIC	DYR	CBL_MET	214:216	Mutation rewiring degron network	0.0833
p.D50H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.D50H	ACH-002215	Lymphoma	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.D50H	BC-3	haematopoietic and lymphoid tissue	COSMIC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.2778
p.E49G	SIDM01472	Hepatocellular Carcinoma	GDSC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation rewiring degron network	0.3056
p.Q163H	ACH-000789	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.3056
p.Q163H	NCI-H810	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.3056
p.P167L	ACH-000789	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.6471
p.P167L	NCI-H810	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.6471
p.E42K	ACH-000867	Lung Cancer	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.591
p.K155N	ACH-000876	Breast Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation substituting flanking lysine	0.1944
p.K155N	MDA-MB-415	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation substituting flanking lysine	0.1944
p.G166C	ACH-000878	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.76
p.G166C	HCC-15	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation altering degron motif	0.76
p.E42Q	ACH-001408	Bladder Cancer	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation altering degron motif	0.5633
p.A176T	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.1667
p.A176T	GEO	large intestine	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	164:170	Mutation rewiring degron network	0.1667
p.K54N	MDA-MB-415	breast	COSMIC	DREALLGVQ	DEG_APCC_DBOX_1	40:48	Mutation blocking phosphorylation signal	0.6111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RCN2

UniProt ID: Q14257

Entrez ID: 5955

Protein name: Reticulocalbin-2 (Calcium-binding protein ERC-55) (E6-binding protein) (E6BP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RCN2 in