DegronMD

Uniprot ID: Q14257

Source protein: Reticulocalbin-2

Source gene: RCN2

Class: DEG_APCC_DBOX_1

Location: 40:48

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8706

ASA_SCORE: 72.1222

COIL: 0.5046

CONS_SCORE: 0.442

DSS_SCORE: 0.3459

HELIX: 0.3173

FCONS_SCORE: 1.0013

RIG_SCORE: 0.7608

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K54N	MDA-MB-415	breast	COSMIC	DREALLGVQ	DEG_APCC_DBOX_1	0.6111
p.E42K	ACH-000867	Lung Cancer	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	0.591
p.E42Q	ACH-001408	Bladder Cancer	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	0.5633
p.E49G	SIDM01472	Hepatocellular Carcinoma	GDSC	DREALLGVQ	DEG_APCC_DBOX_1	0.3056
p.D50E	TCGA-5R-AA1C	LIHC	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50E	DO219545	LIHC	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50N	TCGA-D3-A5GO	SKCM	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50N	DO47419	SKCM	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50A	TCGA-NF-A4X2	UCS	TCGA	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50G	DO38404	STAD	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50H	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50H	ACH-002215	Lymphoma	CCLE	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.D50H	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	DREALLGVQ	DEG_APCC_DBOX_1	0.2778
p.G58C	DO228971	LICA	ICGC	DREALLGVQ	DEG_APCC_DBOX_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14257	Reticulocalbin-2	DEG_APCC_DBOX_1	40:48	DREALLGVQ	APC,CDC20,FZR1	0.8706	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons