DegronMD

Uniprot ID: Q14257

Source protein: Reticulocalbin-2

Source gene: RCN2

Class: DEG_SCF_TRCP1_1

Location: 164:170

E3 ligase: BTRC

DEGRON score: 0.9864

ASA_SCORE: 49.6286

COIL: 0.8627

CONS_SCORE: 0.6062

DSS_SCORE: 0.4209

HELIX: 0.0619

FCONS_SCORE: 1.1246

RIG_SCORE: 0.6357

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R157Q	TCGA-06-5416	GBM	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	0.1389
p.Q163R	TCGA-60-2723	LUSC	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	0.3056
p.E173G	TCGA-DD-AAD0	LIHC	TCGA	DSGPGLS	DEG_SCF_TRCP1_1	0.25
p.R175Q	DO10880	GBM	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.1944
p.R165Q	DO33000	PACA	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	DO229216	THCA	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	DO41572	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	SIDM00846	Cervical Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	SIDM00628	Breast Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	MDA-MB-468	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.R165Q	HeLa	cervix	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.7329
p.S158F	DO41758	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.1667
p.L168I	DO42528	UCEC	ICGC	DSGPGLS	DEG_SCF_TRCP1_1	0.7174
p.K173N	SIDM00630	Breast Carcinoma	GDSC	DSGPGLS	DEG_SCF_TRCP1_1	0.25
p.K173N	MDA-MB-415	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.25
p.Q163H	ACH-000789	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	0.3056
p.Q163H	NCI-H810	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.3056
p.P167L	ACH-000789	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	0.6471
p.P167L	NCI-H810	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.6471
p.K155N	ACH-000876	Breast Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	0.1944
p.K155N	MDA-MB-415	breast	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.1944
p.G166C	ACH-000878	Lung Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	0.76
p.G166C	HCC-15	lung	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.76
p.A176T	ACH-002394	Colon/Colorectal Cancer	CCLE	DSGPGLS	DEG_SCF_TRCP1_1	0.1667
p.A176T	GEO	large_intestine	COSMIC	DSGPGLS	DEG_SCF_TRCP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14257	Reticulocalbin-2	DEG_SCF_TRCP1_1	164:170	DSGPGLS	BTRC	0.9864	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons