DegronMD - Q8IYB7(DIS3L2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2N	TCGA-AX-A1CE	UCEC	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2222
p.S2N	TCGA-AX-A1CE	UCEC	TCGA	DYR	CBL_MET	5:7	Mutation rewiring degron network	0.25
p.S2N	DO42280	UCEC	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2222
p.S2N	DO42280	UCEC	ICGC	DYR	CBL_MET	5:7	Mutation rewiring degron network	0.25
p.H3N	TCGA-EE-A181	SKCM	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.H3N	TCGA-EE-A181	SKCM	TCGA	DYR	CBL_MET	5:7	Mutation rewiring degron network	0.2778
p.H3N	DO37444	SKCM	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.25
p.H3N	DO37444	SKCM	ICGC	DYR	CBL_MET	5:7	Mutation rewiring degron network	0.2778
p.A23V	TCGA-HU-A4GQ	STAD	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.0833
p.A23V	DO47767	STAD	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.0833
p.G14W	TCGA-MN-A4N4	LUAD	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.6714
p.G14W	DO26250	LUAD	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation altering degron motif	0.6714
p.A21S	DO229019	LICA	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.1389
p.S2I	DO229036	LICA	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	6:14	Mutation rewiring degron network	0.2222
p.S2I	DO229036	LICA	ICGC	DYR	CBL_MET	5:7	Mutation rewiring degron network	0.25

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons