DegronMD

Uniprot ID: Q8IYB7

Source protein: DIS3-like exonuclease 2

Source gene: DIS3L2

Class: DEG_APCC_DBOX_1

Location: 6:14

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9125

ASA_SCORE: 101.0889

COIL: 0.8853

CONS_SCORE: 0.2268

DSS_SCORE: 0.6331

HELIX: 0.0886

FCONS_SCORE: 1.0132

RIG_SCORE: 0.7024

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2N	TCGA-AX-A1CE	UCEC	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	0.2222
p.S2N	DO42280	UCEC	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.2222
p.H3N	TCGA-EE-A181	SKCM	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	0.25
p.H3N	DO37444	SKCM	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.25
p.A23V	TCGA-HU-A4GQ	STAD	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	0.0833
p.A23V	DO47767	STAD	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.0833
p.G14W	TCGA-MN-A4N4	LUAD	TCGA	YRMNLRPLG	DEG_APCC_DBOX_1	0.6714
p.G14W	DO26250	LUAD	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.6714
p.A21S	DO229019	LICA	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.1389
p.S2I	DO229036	LICA	ICGC	YRMNLRPLG	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IYB7	DIS3-like exonuclease 2	DEG_APCC_DBOX_1	6:14	YRMNLRPLG	APC,CDC20,FZR1	0.9125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons