DegronMD - P04264(KRT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S221Y	TCGA-06-0221	GBM	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.712
p.S221Y	DO13971	GBM	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.712
p.Y230C	TCGA-52-7810	LUSC	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.Y230C	DO27381	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1111
p.M259I	TCGA-A6-3808	COAD	TCGA	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.1667
p.M259I	DO8408	COAD	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.1667
p.Y270H	TCGA-AJ-A3EL	UCEC	TCGA	DYR	CBL_MET	265:267	Mutation blocking phosphorylation signal	0.6944
p.Y270H	DO41542	UCEC	ICGC	DYR	CBL_MET	265:267	Mutation blocking phosphorylation signal	0.6944
p.Q217L	TCGA-B5-A11R	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.Q217L	DO43787	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.R267Q	TCGA-BR-8590	STAD	TCGA	DYR	CBL_MET	265:267	Mutation altering degron motif	0.7329
p.R267Q	DO233077	GACA	ICGC	DYR	CBL_MET	265:267	Mutation altering degron motif	0.7329
p.R267Q	DO47779	STAD	ICGC	DYR	CBL_MET	265:267	Mutation altering degron motif	0.7329
p.D219Y	TCGA-BS-A0UV	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6214
p.D219Y	DO42793	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.6214
p.N226H	TCGA-CA-6717	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.N226H	DO8264	COAD	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.2222
p.E213K	TCGA-D3-A8GB	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.E213K	DO50280	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1944
p.E271Q	TCGA-DR-A0ZM	CESC	TCGA	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.2222
p.E271Q	DO6254	CESC	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.2222
p.F231I	TCGA-EE-A2M5	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.F231I	DO222423	MELA	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.F231I	DO37425	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.0833
p.R277Q	TCGA-EO-A3AV	UCEC	TCGA	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.0556
p.R277Q	DO52412	UCEC	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.0556
p.R277Q	ACH-001956	Bone Cancer	CCLE	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.0556
p.T220A	TCGA-EO-A3B0	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7139
p.T220A	DO219773	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation altering degron motif	0.7139
p.P229L	TCGA-FW-A3R5	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.P229L	DO37406	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.1389
p.R223K	TCGA-JW-A5VL	CESC	TCGA	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.R223K	DO49976	CESC	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.R267W	DO3458	BRCA	ICGC	DYR	CBL_MET	265:267	Mutation altering degron motif	0.8634
p.R267W	DO230343	COCA	ICGC	DYR	CBL_MET	265:267	Mutation altering degron motif	0.8634
p.N268D	DO23526	LIRI	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.3056
p.E273K	DO220896	MELA	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.1667
p.E273K	ACH-000901	Lung Cancer	CCLE	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.1667
p.D272N	DO222753	MELA	ICGC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.1944
p.Q217H	DO229250	THCA	ICGC	VDTST	DEG_SPOP_SBC_1	218:222	Mutation rewiring degron network	0.3056
p.N268K	SIDM01446	Glioblastoma	GDSC	DYR	CBL_MET	265:267	Mutation rewiring degron network	0.3056

Kaplan plot for KRT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KRT1

UniProt ID: P04264

Entrez ID: 3848

Protein name: Keratin, type II cytoskeletal 1 (67 kDa cytokeratin) (Cytokeratin-1) (CK-1) (Hair alpha protein) (Keratin-1) (K1) (Type-II keratin Kb1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KRT1 in