DegronMD

Uniprot ID: P04264

Source protein: Keratin, type II cytoskeletal 1

Source gene: KRT1

Class: DEG_SPOP_SBC_1

Location: 218:222

E3 ligase: SPOP

DEGRON score: 0.7287

ASA_SCORE: 89.38

COIL: 0.9276

CONS_SCORE: 0.6664

DSS_SCORE: 0.2877

HELIX: 0.0634

FCONS_SCORE: 0.8196

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S221Y	TCGA-06-0221	GBM	TCGA	VDTST	DEG_SPOP_SBC_1	0.712
p.S221Y	DO13971	GBM	ICGC	VDTST	DEG_SPOP_SBC_1	0.712
p.Y230C	TCGA-52-7810	LUSC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.Y230C	DO27381	LUSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.Q217L	TCGA-B5-A11R	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.3056
p.Q217L	DO43787	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.3056
p.D219Y	TCGA-BS-A0UV	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.6214
p.D219Y	DO42793	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.6214
p.N226H	TCGA-CA-6717	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.2222
p.N226H	DO8264	COAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.2222
p.E213K	TCGA-D3-A8GB	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.1944
p.E213K	DO50280	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.1944
p.F231I	TCGA-EE-A2M5	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.0833
p.F231I	DO222423	MELA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.F231I	DO37425	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.T220A	TCGA-EO-A3B0	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.7139
p.T220A	DO219773	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.7139
p.P229L	TCGA-FW-A3R5	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.P229L	DO37406	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.R223K	TCGA-JW-A5VL	CESC	TCGA	VDTST	DEG_SPOP_SBC_1	0.3056
p.R223K	DO49976	CESC	ICGC	VDTST	DEG_SPOP_SBC_1	0.3056
p.Q217H	DO229250	THCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons