DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 2835:2839

E3 ligase: SPOP

DEGRON score: 0.8986

ASA_SCORE: 95.44

COIL: 0.9238

CONS_SCORE: 0.5236

DSS_SCORE: 0.5957

HELIX: 0.0098

FCONS_SCORE: 1

RIG_SCORE: 0.697

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A2847V	TCGA-CV-7568	HNSC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.A2847V	DO14160	HNSC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.S2849L	TCGA-EB-A4XL	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.0556
p.S2849L	DO47401	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.0556
p.E2826K	TCGA-GF-A6C9	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.0833
p.E2826K	DO51254	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.S2825Y	TCGA-GN-A266	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	0.0556
p.S2825Y	DO37432	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	0.0556
p.G2828S	DO227496	LAML	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO228946	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO228960	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO229029	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO229051	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO229053	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO229056	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO45251	LIRI	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.G2828S	DO232656	PBCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.A2847S	DO229018	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons