DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 713:717

E3 ligase: SPOP

DEGRON score: 0.7955

ASA_SCORE: 95.12

COIL: 0.9136

CONS_SCORE: 0.5236

DSS_SCORE: 0.6184

HELIX: 0.011

FCONS_SCORE: 1

RIG_SCORE: 0.6816

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E704G	TCGA-A4-A57E	KIRP	TCGA	VDTST	DEG_SPOP_SBC_1	0.0833
p.E704G	DO44517	KIRP	ICGC	VDTST	DEG_SPOP_SBC_1	0.0833
p.A725V	TCGA-A5-A0G2	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1111
p.A725V	DO41235	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1111
p.P718L	TCGA-AN-A0AM	BRCA	TCGA	VDTST	DEG_SPOP_SBC_1	0.3056
p.P718L	DO4191	BRCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.3056
p.T715I	TCGA-BR-4184	STAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.7078
p.T715I	DO38328	STAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.7078
p.S703Y	TCGA-EO-A3B0	UCEC	TCGA	VDTST	DEG_SPOP_SBC_1	0.0556
p.S703Y	DO219773	UCEC	ICGC	VDTST	DEG_SPOP_SBC_1	0.0556
p.V719M	TCGA-HU-A4G8	STAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.2778
p.V719M	DO47819	STAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.2778
p.T723N	SIDM01520	Oral Cavity Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons