DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 536:540

E3 ligase: SPOP

DEGRON score: 0.8736

ASA_SCORE: 92.7

COIL: 0.8462

CONS_SCORE: 0.5315

DSS_SCORE: 0.6332

HELIX: 0.0122

FCONS_SCORE: 0.8117

RIG_SCORE: 0.6684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V536F	TCGA-55-8614	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	0.7068
p.V536F	DO48885	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	0.7068
p.T530A	TCGA-E7-A541	BLCA	TCGA	VDTST	DEG_SPOP_SBC_1	0.1667
p.T530A	DO44037	BLCA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.E547K	TCGA-QQ-A5VD	SARC	TCGA	VDTST	DEG_SPOP_SBC_1	0.1389
p.E547K	DO222662	MELA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.E547K	DO220252	SARC	ICGC	VDTST	DEG_SPOP_SBC_1	0.1389
p.S546T	DO228960	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.S546T	DO229055	LICA	ICGC	VDTST	DEG_SPOP_SBC_1	0.1667
p.S526F	DO220877	MELA	ICGC	VDTST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P04264	Keratin, type II cytoskeletal 1	DEG_SPOP_SBC_1	218:222	VDTST	SPOP	0.7287	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	536:540	VDTST	SPOP	0.8736	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	713:717	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	949:953	VDTST	SPOP	0.867	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1421:1425	VDTST	SPOP	0.7955	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2717:2721	VDTST	SPOP	0.7959	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	2835:2839	VDTST	SPOP	0.8986	More...
Q9P1A6	Disks large-associated protein 2	DEG_SPOP_SBC_1	836:840	VDTST	SPOP	0.9896	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	424:428	VDTST	SPOP	0.9474	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons